Neuroprotective potentials of candesartan,atorvastatin and their combination against stroke induced motor dysfunction |
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Authors: | Vaibhav Gaur Anil Kumar |
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Institution: | (1) Pharmacology Division, University Institute of Pharmaceutical Sciences, UGC Centre of Advanced Study, Panjab University, Chandigarh, 160014, India; |
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Abstract: | Cerebral ischaemia is a leading cause of death and disability. The objective of the present investigation was to explore the
neuroprotective potentials of candesartan and atorvastatin alone and their combination against the cerebral ischaemia induced
behavioral, biochemical, and mitochondrial dysfunction. Male Wistar rats (200–220 g) were subjected to bilateral common carotid
artery occlusion for 30 min followed by 24 h reperfusion. Candesartan (0.1 and 0.3 mg/kg) and atorvastatin (10 and 20 mg/kg)
were pretreated for 7 days before animals were subjected to ischaemia reperfusion injury. Various behavioral tests (locomotor
activity and rotarod performance), biochemical parameters (Malondialdehyde levels, nitrite concentration, superoxide dismutase
and catalase activity, redox ratio, and GST) and mitochondrial enzyme (Complex I, II, III, and IV) dysfunctions were measured
in cerebral cortex, striatum and hippocampus of the ischaemic brain. Seven days candesartan (0.1 and 0.3 mg/kg) or atorvastatin
(10 and 20 mg/kg) pretreatment significantly attenuated neurobehavioral alterations, oxidative damage and restored mitochondrial
enzyme dysfunction as compared to control (I/R) group. Further, combined treatment of candesartan (0.1 mg/kg) and atorvastatin
(10 mg/kg) significantly potentiated their protective effect which was significant as compared to their effect alone. Present
study suggests the protective effect of candesartan and atorvastatin and their combination against ischaemia reperfusion induced
behavioral and biochemical alterations in rats. |
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