| 重组葡激酶对ICR小鼠的致畸作用研究 |
| |
| 引用本文： | 王取南,魏凌珍,孙美芳,佘素贞,徐德祥. 重组葡激酶对ICR小鼠的致畸作用研究[J]. 癌变．畸变．突变, 2000, 12(3): 169-171 |
| |
| 作者姓名： | 王取南 魏凌珍 孙美芳 佘素贞 徐德祥 |
| |
| 作者单位： | 安徽医科大学卫生毒理学教研究安徽合肥 230032 |
| |
| 摘 要： | 目的：用ＩＣＲ小鼠研究重组葡激酶（ｒ－ＳＡＫ）的致畸作用。方法：ＩＣＲ小鼠于妊娠第６～１５ｄ静脉注射ｒ－ＳＡＫ，剂量为１００ｍｇ／ｋｇ．ｂｗ、３１６ｍｇ／ｋｇ．ｂｗ、１０ｍｇ／ｋｇ．ｂｗ，同时设产阴性对照组和附性对照组，于孕第１８天处死动物，进行各项检查。结果：各剂量组孕鼠增重、活经、胎鼠体重、身长及尾长与阴性对照组比较，差异皆无显著性（Ｐ〉０．０５）；各剂量组胎鼠外观、内脏和骨骼均无畸形发现：结
|
| 关 键 词： | 重组葡激酶 致畸作用 |
| 文章编号： | 1004-616(2000)03-0169-03 |
| 修稿时间： | 1999-10-15 |
STUDY ON THE TERATOGENICITY OF RECOMBINANT STAPHYLOKINASE |
| |
| WANG Qu nan WEI Ling zhen,SUN Mei fang,SHE SU zhen,XU De xiang. STUDY ON THE TERATOGENICITY OF RECOMBINANT STAPHYLOKINASE[J]. Carcinogenesis,Teratogenesis and Mutagenesis, 2000, 12(3): 169-171 |
| |
| Authors: | WANG Qu nan WEI Ling zhen SUN Mei fang SHE SU zhen XU De xiang |
| |
| Abstract: | Purpose: To research the teratogenic effect of recombinant staphylokinase(r-SAK) on ICR mice. Methods: The animals were divided into negative and positive control and three experiment groups which were intravenously given by r-SAK from Day 6 to Day 15 of gestation in dosages of 100mg/kg.bw, 31.6mg/kg.bw and 10mg/kg.bw, respectively. The body growth gains of gestation mice, the numbers, body weight, length and tail length in living fetus and some indicators of embryonic formation were measured. Results: There were no significant differences as compared with negative control groups. Besides, the deformity of the appearances, internal organs and bone in fetal mice was not found. Conclusion: The results indicated that r-SAK had no teratogenic effect on ICR mice in this experiment. |
| |
| Keywords: | recombinant staphylokinase teratogenicity |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
