Ciliary body toxicities of systemic oxcarbazepine and valproic acid treatments: electron microscopic study |
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| Authors: | Güleser Göktaş Zeynep Aktaş Deniz Erdoğan Cemile Merve Seymen Ali Cansu |
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| Affiliation: | 1. Department of Histology and;2. Department of Ophthalmology, Gazi University Medical Faculty, Besevler, Ankara, Turkey,;3. Department of Pediatric Neurology, Karadeniz Technical University Medical Faculty, Trabzon, Turkey, and |
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| Abstract: | Ciliary body is responsible for humour aqueous production in posterior chamber. Valproic acid (VPA) has been widely used for the treatment of epilepsy and other neuropsychiatric diseases such as bipolar disease and major depression. Oxcarbazepine (OXC) is a new anti-epileptic agent that has been used recently for childhood epilepsies such as VPA. In this study, we aimed to investigate the effects of VPA and OXC treatments used as antiepileptic in ciliary body by electron microscopy. In our study, 40 Wistar rats (21 days old) were divided equally into four groups which were applied saline (group 1), VPA (group 2), OXC (group 3) and VPA?+?OXC (group 4). The as-prepared ocular tissues were characterized by transmission electron microscopy (TEM) technique in scanning and transmission electron microscopy (SEM-TEM) (Carl Zeiss EVO LS10). The results confirmed that VPA caused dense ciliary body degeneration. Additionally, ciliary body degeneration in group 4 was supposed to be due to VPA treatment. Ciliary body damage and secondary outcomes should be considered in patients with long-term VPA therapy. |
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| Keywords: | Ciliary body electron microscopy oxcarbazepine valproic acid |
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