Reduced central corneal thickness in patients with isotretinoin treatment |
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| Authors: | Nilay Yuksel Mediha Dilek Ozer Emine Akcay Umut Ozen Selda Uzun |
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| Institution: | 1. Department of Ophthalmology, Ataturk Training and Research Hospital, Ankara, Turkey,;2. Department of Ophthalmology, Necip Fazil City Hospital, Kahramanmaras, Turkey,;3. Department of Ophthalmology, Yildirim Beyazit University, Ankara, Turkey, and;4. Department of Dermatology, Megapark Hospital, Kahramanmaras, Turkey |
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| Abstract: | Context: It is well known that oral isotretinoin treatment causes numerous ocular side-effects.Objective: To investigate the effect of systemic isotretinoin treatment on central corneal thickness (CCT) values due to meibomian gland disease (MGD).Participants: In this prospective study, 47 patients (27 men, 20 women) with nodulocystic acne vulgaris treated with oral isotretinoin (0.8?mg/kg daily) were included.Methods: All patients were analyzed with the Pentacam Scheimpflug topography at baseline, on the 3rd and 6th month of treatment. Main outcome measures were MGD scores and CCT.Results: The mean age of patients was 25.1?±?4.4 years. The mean MGD scores were significantly higher at 3rd month (1.3?±?0.9) and 6th month (1.5?±?1.0) of treatment compared with baseline (1.1?±?0.9) (p?p?p?=?0.038, r?=??0.221).Conclusion: Isotretinoin treatment causes higher MGD scores. A statistically significant decrease in CCT due to MGD was detected at 6th month of treatment. |
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| Keywords: | Acne vulgaris central corneal thickness isotretinoin meibomian gland dysfunction |
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