| Expression of Intercellular Adhesion Molecule-1 in Immune Response of Inner Ear |
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| 引用本文： | 龚树生,曾新力,严臻,汪吉宝. Expression of Intercellular Adhesion Molecule-1 in Immune Response of Inner Ear[J]. 华中科技大学学报(医学英德文版), 1998, 18(4): 208-211. DOI: 10.1007/BF02886474 |
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| 作者姓名： | 龚树生 曾新力 严臻 汪吉宝 |
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| 作者单位： | GONG Shusheng，ZENG Xinli，YAN Zhen，WANG JibaoDepartment of Otorhinolaryngology，Xiehe Hospital，Tongji Medical University，Wuhan 430022 |
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| 基金项目： | This project was supported by a grant from the National Natural Science Foundation of China (No.39400146) |
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| 摘 要： | To understand the role of intercellular adhesion molecule-1 (ICAM-1) in immune response of the inner ear, inner ear immune response was induced in rats by inoculation of keyhole limpet hemocyanine (KLH) into the scala tympani of the animals who had been systemically sensitized. The expression of ICAM-1 in the inner ear was immunohistochemically examined. ICAM-1 was found in the epithelium of the spiral modiolar vein (SMV) with its collecting venules (CVs) as early as 6 h after challenge. Expression of ICAM-1 was observed on the epithelium of the endolymphatic sac (ES) and perisaccular region at 12 h. The intensity of ICAM-1 staining reached its peak within 24-48 h in these sites of the inner ear. By day 28, most specimens were devoid of appreciable staining for ICAM-1.Our study demonstrates that adhesion molecules play an important role in extravasation of inflammatory cells from the systemic circulation in the process of inner ear immune response. It also shows that cytokines that control expression of
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| 收稿时间： | 1998-06-23 |
Expression of intercellular adhesion molecule-1 in immune response of inner ear |
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| Gong Shusheng,Zeng Xinli,Yan Zhen,Wang Jibao. Expression of intercellular adhesion molecule-1 in immune response of inner ear[J]. Journal of Huazhong University of Science and Technology. Medical sciences, 1998, 18(4): 208-211. DOI: 10.1007/BF02886474 |
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| Authors: | Gong Shusheng Zeng Xinli Yan Zhen Wang Jibao |
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| Affiliation: | (1) Department of Otorhinolaryngology, Xiehe Hospital, Tongji Medical University, 430022 Wuhan |
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| Abstract: | To understand the role of intercellular adhesion molecule-1 (ICAM-1) in immune response of the inner ear, inner ear immune response was induced in rats by inoculation of keyhole limpet hemocyanine (KLH) into the scala tympani of the animals who had been systemically sensitized. The expression of ICAM-1 in the inner ear was immunohistochemically examined. ICAM-1 was found in the epithelium of the spiral modiolar vein (SMV) with its collecting venules (CVs) as early as 6 h after challenge. Expression of ICAM-1 was observed on the epithelium of the endolymphatic sac (ES) and perisaccular region at 12 h. The intensity of ICAM-1 staining reached its peak within 24 - 48 h in these sites of the inner ear. By day 28, most specimens were devoid of appreciable staining for ICAM-1. Our study demonstrates that adhesion molecules play an important role in extravasation of inflammatory cells from the systemic circulation in the process of inner ear immune response. It also shows that cytokines that control expression of adhesion molecules may be released by cells outside ES, besides those cells in the ES. |
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| Keywords: | labyrinth autoimmunity intercellular adhesion molecule-1 en-dolymphatic sac |
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