麝香酮在大鼠、家兔和狗体内的药代动力学

麝香酮在大鼠体内的药时过程符合二室开放模型,在家兔和狗体内的药时过程则符合三室开放模型。大鼠、家兔和狗之间的药代动力学过程存在着显著的种属差异,大鼠iv麝香酮12,18和24 mg/kg三种剂量间的药代动力学主要参数无显著性差异。iv给药大鼠的T_1/2B为118.1～131.2min。家兔和狗的T_1/2B分别为24.9和30.0 min,T_1/2γ分别为331.9和366.4 min。大鼠、家兔和狗三b种动物的V_ss分别为23.0,51.7和7.3 L/kg.V_c分别为2.33,2.13和0.38 L/kg。

PHARMACOKINETICS OF MUSCONE IN RATS, RABBITS AND DOGS

The plasma concentration-time course of muscone in rats after a single iv administration fitted well to a two-compartment open model, and those in rabbits and dogs were all comformod to a three-compartment open model. Significant species differences were observed in the pharmacokinetic parameters among rats, rabbits and dogs, while no significant differences were found among the three dosages of 12,18 and 24 mg/kg after iv administration to rats. In rats, the T_1/2β was found to be 118. 1～131.2 min. In rabbits and dogs, the T_1/2β were 24.9 and 30. 0 min, respectively and the T_1/2γ were 331.9 and 366.4 min, respectively. In rats, rabbits and dogs, the V_ss were 23. 0, 51.7 and 7. 3 L/kg, respectively, and the V_C were 2.33, 2. 13 and 0. 38 L/kg, respectively.