| 毛茛甙的抗诱变作用及代谢转化 |
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| 引用本文： | 李润沼,裴惠平,籍秀娟. 毛茛甙的抗诱变作用及代谢转化[J]. 药学学报, 1993, 28(7): 481-485 |
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| 作者姓名： | 李润沼 裴惠平 籍秀娟 |
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| 作者单位： | 中国医学科学院药物研究所,北京100050;*北京医科大学天然药物及仿生药物国家重点实验室,北京100083;**河南新乡市中心医院,新乡453000 |
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| 摘 要： | 研究表明,毛茛甙可显著抑制MMC和MMS等诱变剂对沙门氏菌TA100和TA102回复突变作用;对MMC诱发的小鼠PEC徽核抑制率达56.5%。代谢研究表明:毛茛甙抑制DNA生物合成的作用可被肝微粒体酶和胞浆液分别降低46和12%;RP-HPLC测定显示,体外毛茛甙可被肝微粒代谢转化。
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| 关 键 词： | 毛茛甙 抗诱变作用 代谢转化 |
| 收稿时间： | 1992-06-22 |
ANTIMUTAGENIC ACTIVITY AND METABOLIC TRANSFORMATION OF RANUNCULIN BY RAT LIVER MICROSOMES |
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| RZ Li,HP Pei and XJ Ji. ANTIMUTAGENIC ACTIVITY AND METABOLIC TRANSFORMATION OF RANUNCULIN BY RAT LIVER MICROSOMES[J]. Acta pharmaceutica Sinica, 1993, 28(7): 481-485 |
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| Authors: | RZ Li HP Pei XJ Ji |
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| Abstract: | Ranunculin (RAN) was shown to be an antimutagenic agent selectively against mitomycin C (MMC) or methyl methane sulfanate (MMS) treated Salmonella typhimminum TA100/TA102. It decreased the formation of micronucleus of MMC induced polychromatic erythrocytes (PEC) from 46±9.2% to 20±6% in mice. The inhibition of RAN on the incorporation of 3H-TdR into DNA disappeared after incubation with rat liver microsomes and cytoplasm since RAN was found to be metablized by rat liver microsomes in vitro, resulting in a new absorbance peak at 258 nm, determined by RP-HPLC. The data show that RAN may have both antimutagen and antitumor activity, but the latter action may disappear by metabolic transformation. |
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| Keywords: | Antimutagenic activity Metabolic transform Ranunculin |
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