| 薄层色谱选择性优化新方法及其在药物分析中的应用 |
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| 引用本文： | 胡育筑,何华,赖宇红,倪坤仪. 薄层色谱选择性优化新方法及其在药物分析中的应用[J]. 药学学报, 1993, 28(1): 50-56 |
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| 作者姓名： | 胡育筑 何华 赖宇红 倪坤仪 |
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| 作者单位： | 中国药科大学,南京210009 |
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| 摘 要： | 提出了一种适用于薄层色谱选择性优化新方法——逐步登高法和一种新的综合优化指标——NRC,并成功地应用于丹参注射液、人工牛黄和头孢噻吩钠的薄层色谱展开剂系统的优化。
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| 关 键 词： | 薄层色谱 逐步登高法 综合优化指标 |
| 收稿时间： | 1992-01-28 |
NEW METHOD FOR SELECTIVITY OPTIMIZATION IN THIN LAYER CHROMATOGRAPHY AND ITS APPLICATION IN PHARMACEUTICAL ANALYSIS |
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| YZ Hu,H He,YH Led and KY Ni. NEW METHOD FOR SELECTIVITY OPTIMIZATION IN THIN LAYER CHROMATOGRAPHY AND ITS APPLICATION IN PHARMACEUTICAL ANALYSIS[J]. Acta pharmaceutica Sinica, 1993, 28(1): 50-56 |
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| Authors: | YZ Hu H He YH Led KY Ni |
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| Abstract: | A new experimental design method named the step climbing method (SCM), as well as a new global criterion (NRC), are proposed for the selectivity optimization of thin layer chromatography. The method offers chromatographers a convenient means to decide the optimum developer composition for thin layer chromatography. The principle of the method is described, and examples of applications in pharmaceutical analysis are given to certify the feasibility of the method. Clearly, it may also be used for the selectivity optimization in high performance liquid chromatography. |
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| Keywords: | Step climbing method Global optimization criterion Thin layer chromatography |
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