| 1-乙基-6-氟-1,4-二氢-4-氧代-7-(4-芳酰硫代氨甲酰基-1-哌嗪基)-3-喹啉羧酸的合成及抗菌作用 |
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| 引用本文： | 贾学顺,王玉炉,何方淑,单英芳,李用芳,王昀.1-乙基-6-氟-1,4-二氢-4-氧代-7-(4-芳酰硫代氨甲酰基-1-哌嗪基)-3-喹啉羧酸的合成及抗菌作用[J].药学学报,1993,28(6):477-480. |
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| 作者姓名： | 贾学顺 王玉炉 何方淑 单英芳 李用芳 王昀 |
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| 作者单位： | 河南师范大学化学系,新乡453002;**河南师范大学生物系,新乡453002;***同济医科大学医学系,学生 |
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| 摘 要： | Thirteen new 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(4-aroyl-thiocarbamoyl- 1 piperazinyl)-3-quinoline carboxylic acids were prepared, Their structures were characterized by elemental analysis, IR, HNMR and MS spectra.Preliminary pharmacological tests indicated that some of compounds Ia～m possess strong inhibiting activity against Escherichia coli, Bacillus subtilis and Proteus at concentration of 100 μg/ml.
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| 关 键 词： | 喹啉羧酸 芳酰基硫代氨基甲酰衍生物 抗菌作用 氟哌酸 |
| 收稿时间： | 1992-07-11 |
SYNTHESIS AND ANTIBACTERIAL ACTION OF 1-ETHYL-6-FLUORO-1, 4-DIHYDRO- 4-OXO-7-(4-AROYLTHIOCARBAMOYL-1 -PIPERAZINYL)- 3-QUINOLINE CARBOXYLIC ACIDS |
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| XS Jia,YL Wang,FS He,YF Shan,YF Li and Y Wang.SYNTHESIS AND ANTIBACTERIAL ACTION OF 1-ETHYL-6-FLUORO-1, 4-DIHYDRO- 4-OXO-7-(4-AROYLTHIOCARBAMOYL-1 -PIPERAZINYL)- 3-QUINOLINE CARBOXYLIC ACIDS[J].Acta Pharmaceutica Sinica,1993,28(6):477-480. |
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| Authors: | XS Jia YL Wang FS He YF Shan YF Li and Y Wang |
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| Abstract: | Thirteen new 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(4-aroyl-thiocarbamoyl- 1 piperazinyl)-3-quinoline carboxylic acids were prepared, Their structures were characterized by elemental analysis, IR, HNMR and MS spectra.Preliminary pharmacological tests indicated that some of compounds Ia～m possess strong inhibiting activity against Escherichia coli, Bacillus subtilis and Proteus at concentration of 100 μg/ml. |
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| Keywords: | Aroylthiocarbamoyl derivatives Antibacterial action Norfloxacin Quinoline carboxylic acid |
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