| 铀促排药物研究Ⅵ:2,3-二羟基-4-甲氧羰基苄基胺羧酰胺螯合剂的合成 |
| |
| 引用本文： | 覃兆海,谢毓元.铀促排药物研究Ⅵ:2,3-二羟基-4-甲氧羰基苄基胺羧酰胺螯合剂的合成[J].药学学报,1993,28(8):619-622. |
| |
| 作者姓名： | 覃兆海 谢毓元 |
| |
| 作者单位： | 中科院上海药物研究所,上海200031 |
| |
| 摘 要： |
|
| 关 键 词： | 铀促排药物 N-羧甲基-N-(取代胺甲酰甲基)-2 3-二羟基-4-甲氧羰基苄胺 |
| 收稿时间： | 1992-09-18 |
STUDIES ON URANIUM MOBILIZATION AGENTS VI: SYNTHESIS OF 2,3-DIHYDROXY-4-CARBOMETHOXYBENZYL AMINOCARBOXYLIC ACID AMIDES CHELATING AGENTS |
| |
| ZH Qin and YY Xie.STUDIES ON URANIUM MOBILIZATION AGENTS VI: SYNTHESIS OF 2,3-DIHYDROXY-4-CARBOMETHOXYBENZYL AMINOCARBOXYLIC ACID AMIDES CHELATING AGENTS[J].Acta Pharmaceutica Sinica,1993,28(8):619-622. |
| |
| Authors: | ZH Qin and YY Xie |
| |
| Abstract: | In searching for new chelation therapy drugs against uranium intoxication, a series of N-carboxymethyl-N- (substituted carbamoylmethyl)- 2, 3- dihydroxy- 4- carbomethoxybenzylamine was synthesized starting with o-vanillin. The effect on detoxieation of UO2 (NO3)2, CuSO4 and NiCl2 in mice was tested. Some of them (IVa, IVd, IVf and IVg) were shown to be good antidotes for acute uranium intoxication, but all were less effective for Cu2+ and Ni2+. |
| |
| Keywords: | N-Carboxymethyl-N-(substituted carbamoylmethyl)-2 3-dihydroxy-4-carbomethoxybenzylamine Uranium mobilization agents |
| 本文献已被 维普 等数据库收录！ |
| 点击此处可从《药学学报》浏览原始摘要信息 |
| 点击此处可从《药学学报》下载免费的PDF全文 |
|
