| 3,6-[二甲氨基]-二苯骈碘因甲酸盐对豚鼠单—心室肌细胞动作电位和慢内向钙电流的影响 |
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| 引用本文： | 崔毅,谭月华.3,6-[二甲氨基]-二苯骈碘因甲酸盐对豚鼠单—心室肌细胞动作电位和慢内向钙电流的影响[J].药学学报,1993,28(7):504-506. |
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| 作者姓名： | 崔毅 谭月华 |
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| 作者单位： | 第四军医大学药理教研室,西安710032 |
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| 摘 要： | 采用全细胞电压钳技术,观察了3,6-二甲氨基]-二苯骈碘因甲酸盐(IHC-64)对豚鼠单一心室肌细胞动作电位和慢内向钙电流(Isi)的影响。结果表明,IHC-64 20和200 μmol/L可明显缩短APD20和APD90。予先给予钙通道阻滞剂尼索地平可取消IHC-64缩短APD20的作用。在电压钳条件下,上述浓度的IHC-64对Isi有明显的抑制作用,Isi由给药前的1.92±0.41 nA分别降低至给药后1.73±0.50 nA(P<0.05)和0.62±0.38 nA(P<0.01).提示IHC-64可能对心肌细胞钙通道有阻滞作用。
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| 关 键 词： | 3 6-[二甲氨基]-二苯骈碘因甲酸盐 动作电位 钙通道 心肌 |
| 收稿时间： | 1992-10-26 |
EFFECTS OF 3,6-DIMETHYLAMINO-DIBENZOPYRIODONIUM FORMIATE ON ACTION POTENTIAL AND SLOW INWARD CALCIUM CURRENT IN ISOLATED GUINEA PIG VENTRICULAR MYOCYTES |
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| Y Cui and YH Tan.EFFECTS OF 3,6-DIMETHYLAMINO-DIBENZOPYRIODONIUM FORMIATE ON ACTION POTENTIAL AND SLOW INWARD CALCIUM CURRENT IN ISOLATED GUINEA PIG VENTRICULAR MYOCYTES[J].Acta Pharmaceutica Sinica,1993,28(7):504-506. |
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| Authors: | Y Cui and YH Tan |
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| Abstract: | The effects of 3, 6-dimethylamino-dibenzopyriodonium formiate (IHC-64) on action potential and slow inward calcium current (Isi) were investigated in isolated guinea pig ventricular myocytes using whole cell voltage clamp recording. IHC-64 (20 and 200 μmol/L) was shown to markedly decrease APD20 and APD90. However, in the presence of nisoldipine, no obvious effects of IHC-64 on APD20 could be detected. Under voltage clamp conditions, IHC-64 (20 and 200 μmol/L) caused a significant decrease in Isi. The results indicate that IHC-64 can block the calcium channels in isolated guinea pig ventricular myocytes. |
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| Keywords: | Action potentials Calcium channels Myocardium 3 6-Dimethylamino- dibenzopyriodonium formiate |
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