兰索拉唑脂质体的制备及其药剂学性质考察

目的:研究兰索拉唑阳离子脂质体的制备方法并考察其药剂学性质。方法:采用正交设计筛选处方,乙醇注入法制备兰索拉唑脂质体;超滤法测定其包封率;用透射电镜观察脂质体的外观形态,并用粒径分析仪和Zeta电位仪分别测定脂质体的粒径和Zeta电位;进一步考察脂质体的释放规律。结果:所得脂质体包封率约为(80±1.23)%;形态为粒径均匀的球形和类球形,粒径为(184±21)nm,Zeta电位为(36.1±5)mV;脂质体的体外释放符合一级方程;具有较好的稳定性。结论:优选得到的脂质体处方和制备工艺合理、稳定,其体外释放具有缓释特点。

Preparation and Pharmaceutical Characterization of Lansoprazole Liposomes

OBJECTIVE:To prepare and characterize lansoprazole(LAP) cationic liposomes. METHODS:Liposomes were prepared by ethanol injection technique.An orthogonal test was utilized to optimize the formulation and preparation of LAP liposomes.The encapsulation efficiency was determined by ultrafiltration.The morphological examination of LAP liposomes was performed using transmission electron microscopy.The particle size and Zeta potential of the liposomes were measured.The release rate of LAP from liposomes was tested. RESULTS:The liposomes with spherical or ellipsoidal shape and better stability featured the encapsulation efficiency of(80±1.23)%,the mean partical size of (184±21)nm,and Zeta potential of (36.1±5)mV.The release kinetics in vitro obeyed first-order equation.The stability of LAP was better. CONCULSION:The selected formulation and preparation technic of lansoprazole liposomes were rational and stable and liposomes featured a sustained release in vitro.