| 汉防已甲素对小鼠遗传毒性的研究 |
| |
| 引用本文： | 金焕荣,段志文,赵肃,张越,王任群. 汉防已甲素对小鼠遗传毒性的研究[J]. 沈阳医学院学报, 1997, 0(3) |
| |
| 作者姓名： | 金焕荣 段志文 赵肃 张越 王任群 |
| |
| 作者单位： | 沈阳医学院预防医学系劳动卫生学教研室(金焕荣，段志文，赵肃，张越)，沈阳医学院预防医学系劳动卫生学教研室(王任群) |
| |
| 摘 要： | 通过精子畸形试验、微核实验及姐妹染色单体交换试验,进行了汉防己甲素对小鼠遗传毒性的研究。结果表明,汉防己甲素组的小鼠精子畸形率及小鼠骨髓细胞微核率显著增高,且存在剂量—反应关系。但小鼠姐妹染色单体交换频率的改变不显著。表明该药对实验动物具有遗传毒性。
|
| 关 键 词： | 汉防己甲素 微核 姐妹染色单体交换(SCE) 精子畸形 |
Hereditary Toxicity of Tetrandrine on Mice |
| |
| Jin Huanrong,Duan Zhiwen,Zhao Su,et al.. Hereditary Toxicity of Tetrandrine on Mice[J]. Journal of Shenyang Medical College, 1997, 0(3) |
| |
| Authors: | Jin Huanrong Duan Zhiwen Zhao Su et al. |
| |
| Affiliation: | Department of Occupational Health |
| |
| Abstract: | The hereditary toxicity of tetrandrine on mice was studied by sperm deformity test, marrow micronucleus test and sister chromatid exchange. The results showed that the rates of spermatic deformity and marrow cells micronucleus in mice were increased significantly in groups treated with tetrandrine, and there was a dose -response relationship, but the chang of the frequencies of sister chromatid exchanges was not obvious. It is concluded that tetrandrine has hereditary toxicity to experimental aninal. |
| |
| Keywords: | tetrandrme micronucleus ( sister chrornatid exchanges sperm ditormity |
| 本文献已被 CNKI 等数据库收录！ |
