毛囊黏蛋白病一例

患者女,60岁,因面部结节、斑块1年余就诊.患者以面部结节和浸润性斑块为皮损表现.皮肤科检查:前额见皮色和淡红色结节,左下颏见浸润性斑块,上覆黄色痂皮.组织病理检查示,真皮及皮下血管、附属器周围以淋巴细胞为主的炎症细胞浸润,毛囊上皮网状变性,并形成囊腔,经阿新蓝染色见囊腔中大量黏蛋白沉积.治疗方面给予阿维A和泼尼松口服,局部外用莫米松乳膏联合异维A酸凝胶等治疗,2个月后痊愈.

Follicular mucinosis: a case report

A case of follicular mucinosis is reported. A 60-year-old female was admitted to the hospital for facial nodules and infiltrated plaques over 1 year. Dermatological examination revealed skin-colored or pink nodules on the forehead and infiltrated plaques on the left chin covered with yellow crusts. The biopsy of a skin lesion demonstrated a mixed infiltrate of inflammatory cells which were predominated by lymphocytes, in dermis and around subcutaneous blood vessels and appendages. Reticular degeneration of follicular epithelial cells and formation of cysts were also observed. Alcian blue stain displayed massive mucin deposition in cyst cavity. After treatment with oral acitretin and prednisone and topical mometasone cream and isotretinoin gel for 2 months, the lesions disappeared.