Effects of para-chlorophenylalanine and 5-hydroxytryptophan on alcohol intake in the rat |
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| Authors: | I Geller |
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| Affiliation: | Department of Psychiatry, Psychopharmacological Research Division, Texas Tech University School of Medicine, Lubbock, Texas 79409, USA |
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| Abstract: | Para-chlorophenylalanine, the tryptophan hydroxylase inhibitor that depletes serotonin selectively, increased alcohol intake in rats. 5-Hydroxytryptophan, the serotonin percursor, reduced alcohol intake. These findings suggest that alcohol preference in the rat may be related to the brain tryptaminirgic system. |
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| Keywords: | Alcohol 5-HTP pCPA Serotonin |
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