| 黄柏微丸的制备和体外溶出度考察 |
| |
| 引用本文： | 杨思源,叶雲.黄柏微丸的制备和体外溶出度考察[J].北方药学,2011,8(6):29-30. |
| |
| 作者姓名： | 杨思源 叶雲 |
| |
| 作者单位： | 广西中医学院,南宁,530001;中国人民解放军第三〇三医院,南宁,530021 |
| |
| 摘 要： | 目的：制备黄柏微丸并进行处方优化,考察微丸的体外溶出度。方法：用挤出滚圆造粒机制备黄柏微丸,优化制剂处方组成;采用高效液相色谱法以盐酸小檗碱有为指标,对其体外溶出度进行考察。结果：制得微丸圆整度好,大小均匀,收率在82%以上。盐酸小檗碱的溶出度60min内达88%以上。结论：本法研制的黄柏微丸,处方合理,工艺可行。
|
| 关 键 词： | 黄柏微丸 挤出滚圆法 体外溶出度 |
Study on the preparation and in vitro dissolution of Huangbai pellets |
| |
| Yang Siyuan,Ye Yun.Study on the preparation and in vitro dissolution of Huangbai pellets[J].BEIFANG YAOXUE,2011,8(6):29-30. |
| |
| Authors: | Yang Siyuan Ye Yun |
| |
| Institution: | 1.Gguangxi University of Traditional Chinese Medcine Guangxi Nan ning 530001;2.Army liberation people’s of hospital 303 Guangxi Nan ning 530021) |
| |
| Abstract: | Objective：To prepare Huangbai pellets,optimize formulation and investigate dissolution in vitro Methods：Huangbai pellets were prepared using extrusion-spheronization.The effect of excipients on plastic process was investigated to obtain optimal formulation.The dissolution of baicalin berberine from the pellets were determined by HPLC.Results：Huangbai pellets prepared presented perfect sphericity,narrow diameter distribution and yield over 82%.in vitro dissolution of and baicalin berberine were more than 88% within 60min respectively.Conclusions：The formulation and process of preparring Huangbai pellets are reasonable and effective. |
| |
| Keywords: | Huangbai pellets Extrusion-spheronization In vitro dissolution |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
