雾化吸入硝酸甘油对呼吸衰竭新生儿ET-1和血气分析的影响

目的:探讨硝酸甘油雾化吸入对新生儿呼吸衰竭的治疗作用。方法:将110例呼吸衰竭的新生儿分为硝酸甘油组和对照组各55例。硝酸甘油组给予雾化吸入硝酸甘油20μg/(kg.次),4次/d,连用3天;对照组给予雾化吸入等容量生理盐水4次/d,连用3天。在治疗前后测定血内皮素-1(ET-1)。观察记录TcSO2达93%的时间,CPAP时间和住院时间。结果:治疗前两组ET-1、TcSO2水平差异无统计学意义;治疗后硝酸甘油组PaO2、PaCO2等明显改善(P<0.05);ET-1显著降低(t=3.65,P<0.01)。硝酸甘油组TcSO2达93%的时间及使用CPAP和住院时间均比对照组明显缩短(P<0.01)。结论:硝酸甘油雾化吸入治疗新生儿呼吸衰竭具有较好的临床疗效。

Effect of aerosol inhalation of nitroglycerin on ET-1 and blood gas analysis of neonates with respiratory failure

Objective:To explore the therapeutic effect of aerosol inhalation of nitroglycerin on neonates with respiratory failure. Methods:110 neonates with respiratory failure were divided into nitroglycerin group and control group,55 neonates in each group;the neonates in nitroglycerin group were treated with aerosol inhalation of nitroglycerin,20 μg/kg once,4 times per day for 3 days;the neonates in control group were treated with aerosol inhalation of normal saline of equivalent volume,4 times per day for 3 days.The levels of endothelin-1(ET-1) in blood were detected before and after treatment;the time of TcSO2 reaching 93%,CPAP time and hospitalization time were observed and recorded. Results:Before treatment,there was no significant difference in ET-1 and TcSO2 levels between the two groups.After treatment,PaO2 and PaCO2 levels in nitroglycerin group were improved significantly(P<0.05);the level of ET-1 decreased significantly(t=3.65,P<0.01);the time of TcSO2 reaching 93%,CPAP time and hospitalization time in nitroglycerin group were significantly shorter than those in control group(P<0.01). Conclusion:The clinical efficacy of aerosol inhalation of nitroglycerin in treatment of neonates with respiratory failure is good.