抗子宫内膜抗体、抗精子抗体与子宫内膜异位症关系的研究

目的:探讨子宫内膜异位症患者血清中抗子宫内膜抗体(EMAb)、抗精子抗体(ASAb)的表达情况,并进一步研究EMAb、ASAb与子宫内膜异位症不孕的关系。方法:应用酶联免疫吸附试验(ELISA)法检测164例子宫内膜异位症患者(EMT组)血清中EMAb、ASAb阳性情况,并与健康妇女组(对照组)进行比较。结果:EMT组EMAb的阳性率为59.76%(98/164),显著高于对照组7.32%(12/164)(P0.01);EMT组ASAb阳性率15.85%(26/164)显著高于对照组2.44%(4/164)(P0.01);EMT组不孕症患者EMAb阳性率81.03%(47/58)与无不孕组48.11%(51/106)比较差异有统计学意义(P0.05);ASAb的阳性率为36.21%(21/58)显著高于对照组4.72%(5/106)(P0.01)。结论:EMAb、ASAb与子宫内膜异位症相关密切,EMAb、ASAb是导致子宫内膜异位症不孕的原因之一,且EMAb可作为子宫内膜异位症的辅助诊断指标。

Study of the relationship between EMAb,ASAb and endometriosis

Objective:To study the expression of endometrial antibody (EMAb) and anti-sperm antibody (ASAb) in the serum of endometriosis,and to reveal the relationship between EMAb,ASAb and endometriosis.Methods:Enzyme linked immunosorbent assay (ELISA) was applied to detect EMAb and ASAb in 164 serum samples of endometriosis (EMT group) and 164 healthy women (control group).Results:The positive rate of EMAb 59.76% (98 /164) in the EMT group that significantly higher than that of control group 7.32% (12 /164) (P < 0.01),and the positive rate of ASAb 15.85% (26 /164) was also higher than that of control group 2.44% (4 /164) (P < 0.01) ;The positive rate of EMAb 81.03% (47 /58) in infertility group was significantly higher than that of fertility group 48.11% (51 /106) (P < 0.05),and the positive rate of ASAb 36.21% (21 /58) was higher than that of control group 4.72% (5 /106) (P <0.01).Conclusion:EMAb and ASAb are closely related to endometriosis;EMAb and ASAb are part of reasons for infertility of endometriosis and EMAb can be an index for diagnosis of endometriosis.