| 金属硫蛋白与肿瘤增殖抗原在卵巢上皮性肿瘤组织中的表达及意义 |
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| 引用本文： | 高迎春,张爽.金属硫蛋白与肿瘤增殖抗原在卵巢上皮性肿瘤组织中的表达及意义[J].中国妇幼保健,2011,26(6):907-908. |
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| 作者姓名： | 高迎春 张爽 |
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| 作者单位： | 辽宁医学院附属第一医院,辽宁锦州,121000 |
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| 摘 要： | 目的:研究金属硫蛋白(MT)和肿瘤增殖抗原(Ki-67)在卵巢上皮性肿瘤组织中的表达及相关性和临床意义。方法:采用免疫组化SP法及半定量分析法,检测105例卵巢上皮性肿瘤病理标本中的MT及Ki-67蛋白表达。结果:MT在卵巢癌及正常组织中表达有差异(P<0.01),Ki-67在不同组织学类型卵巢肿瘤间表达无明显差异(P>0.05);MT与Ki-67的表达强度恶性肿瘤高于正常、良性、交界性肿瘤(P<0.05),临床Ⅲ、Ⅳ期,病理2、3级的恶性肿瘤高于临床Ⅰ、Ⅱ期,病理1级者(P<0.01);MT与Ki-67的表达强度在恶性上皮性卵巢肿瘤中有显著相关性(P<0.05)。结论:组织中MT、Ki-67的表达强度与卵巢肿瘤的性质有关,MT和Ki-67可能作为卵巢肿瘤的预后预测参考指标。
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| 关 键 词： | 卵巢癌 金属硫蛋白 肿瘤增殖抗原 |
Expressions of metallothionein and tumor proliferating antigen in epithelial ovarian carcinoma tissues and their significances |
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| GAO Ying-Chun,ZHANG Shuang.Expressions of metallothionein and tumor proliferating antigen in epithelial ovarian carcinoma tissues and their significances[J].Maternal and Child Health Care of China,2011,26(6):907-908. |
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| Authors: | GAO Ying-Chun ZHANG Shuang |
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| Institution: | GAO Ying-Chun,ZHANG Shuang.The First Hospital Affiliated to Liaoning Medical College,Jinzhou 121000,Liaoning,China |
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| Abstract: | Objective:To study the expressions of metallothionein and tumor proliferating antigen(Ki-67) in epithelial ovarian carcinoma tissues,analyze their correlation and clinical significances.Methods:Immunohistochemical SP method and semi-quantitative analysis were used to detect the expressions of metallothionein and Ki-67 protein in pathological samples of epithelial ovarian carcinoma.Results:There was significant difference in expression level of metallothionein between ovarian cancer and normal ovary(P<0.01),... |
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| Keywords: | Ovarian cancer Metallothionein Tumor proliferating antigen |
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