| 子宫内膜癌组织中PTEN及PI3K的表达及临床意义 |
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| 引用本文： | 佟晓红,闫志红,王瑛坚,邹积艳. 子宫内膜癌组织中PTEN及PI3K的表达及临床意义[J]. 中国妇幼保健, 2011, 26(5): 740-742 |
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| 作者姓名： | 佟晓红 闫志红 王瑛坚 邹积艳 |
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| 作者单位： | 1. 吉林省长春市妇产医院,130042
2. 吉林大学中日联谊医院 |
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| 摘 要： | 目的:应用组织芯片技术探讨PTEN及PI3K表达与子宫内膜癌临床病理特征之间的关系及其表达相关性。方法:收集62例子宫内膜病理标本,应用组织芯片技术及免疫组化法检测PTEN及PI3K的表达。结果:PTEN和PI3K在子宫内膜良、恶性组织中阳性表达率相比,差异有统计学意义;在子宫内膜癌高中分化组与低分化组中阳性表达率相比,差异有统计学意义;在无肌层浸润或浸润深度≤1/2组与浸润深度>1/2组中阳性表达率相比,差异有统计学意义;PI3K在无淋巴结转移的子宫内膜癌中及有转移者中阳性表达率相比,差异有统计学意义;PTEN阳性表达率与PI3K阳性表达率呈负相关(γ=-0.631,P<0.05)。结论:PTEN阳性表达与子宫内膜癌组织学分级及肿瘤侵袭性呈负相关;PI3K阳性表达与子宫内膜癌组织学分级、肿瘤侵袭性及淋巴结转移呈正相关;二者在子宫内膜癌发生和发展中呈拮抗作用,表达呈负相关。组织芯片用于多因素比较研究具有高效率、质控好的优点,是一种可靠、快速、经济的高通量分析工具。监测PTEN和PI3K表达,对判断肿瘤恶性程度有重要意义。
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| 关 键 词： | 子宫内膜癌 PTEN PI3K 免疫组织化学 组织芯片 |
Expressions of PTEN and PI3K in endometrial carcinoma tissues and their clinical significances |
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| TONG Xiao-Hong,YAN Zhi-Hong,WANG Ying-Jian et al.Hospital for Gynecology , Obstetrics,Changchun ,Jilin,China. Expressions of PTEN and PI3K in endometrial carcinoma tissues and their clinical significances[J]. Maternal and Child Health Care of China, 2011, 26(5): 740-742 |
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| Authors: | TONG Xiao-Hong YAN Zhi-Hong WANG Ying-Jian et al.Hospital for Gynecology Obstetrics Changchun Jilin China |
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| Affiliation: | TONG Xiao-Hong,YAN Zhi-Hong,WANG Ying-Jian et al.Hospital for Gynecology and Obstetrics,Changchun 130042,Jilin,China |
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| Abstract: | Objective:To explore the expressions of PTEN and PI3K and the relationship with clinicopathological characteristics of endometrial carcinoma by tissue microarray technology.Methods:The pathological specimens of endometrium were collected from 62 cases,tissue microarray technology and immunohistochemical method were used to detect the expressions of PTEN and PI3K.Results:There was significant difference in positive rates of PTEN and PI3K between endometrial benign tissues and endometrial malignant tissues;th... |
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| Keywords: | PTEN PI3K |
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