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| Coeliac disease in Dutch patients with Hashimoto＇s thyroiditis and vice versa | |
| 引用本文： | Hadithi M,de Boer H,Meijer JW,Willekens F,Kerckhaert JA,Heijmans R,Pe?a AS,Stehouwer CD,Mulder CJ.Coeliac disease in Dutch patients with Hashimoto＇s thyroiditis and vice versa[J].世界胃肠病学杂志(英文版),2007,13(11):1715-1722. |
| 作者姓名： | Hadithi M de Boer H Meijer JW Willekens F Kerckhaert JA Heijmans R Peña AS Stehouwer CD Mulder CJ |
| 摘 要： | |
| 关 键 词： | 荷兰患者 乳糜泄 桥本式甲状腺炎 自体免疫疾病 |
| 收稿时间： | 2006 Nov 24 |
Coeliac disease in Dutch patients with Hashimoto's thyroiditis and vice versa |
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| Hadithi Muhammed,de Boer Hans,Meijer Jos W R,Willekens Frans,Kerckhaert Jo A,Heijmans Roel,Pe?a Amado Salvador,Stehouwer Coen D A,Mulder Chris J J.Coeliac disease in Dutch patients with Hashimoto's thyroiditis and vice versa[J].World Journal of Gastroenterology,2007,13(11):1715-1722. | |
| Authors: | Hadithi Muhammed de Boer Hans Meijer Jos W R Willekens Frans Kerckhaert Jo A Heijmans Roel Peña Amado Salvador Stehouwer Coen D A Mulder Chris J J |
| Institution: | 1. Department of Gastroenterology, Rijnstate Hospital, PO Box 9555, 6800 TA Arnhem, The Netherlands 2. Department of Endocrinology, Rijnstate Hospital,PO Box 9555, 6800 TA Amhem, The Netherlands 3. Department of Pathology, Rijnstate Hospital, PO Box 9555, 6800 TA Amhem, The Netherlands 4. Laboratory of Biochemistry, Rijnstate Hospital,PO Box 9555, 6800 TA Arnhem, The Netherlands 5. Laboratory of Biochemistry Immunology,Rijnstate Hospital, PO Box 9555, 6800 TA Arnhem, The Netherlands 6. Laboratory of Immunogenetics, VU University Medical Center, Amsterdam, PO Box 7057,1007 MB Amsterdam, The Netherlands 7. Department of Internal Medicine,University Hospital Maastricht, P. Debyelaan 25, 6229 HX Maastricht, The Netherlands |
| Abstract: | AIM To define the association between Hashimoto's thyroiditis and coeliac disease in Dutch patients.METHODS A total of 104 consecutive patients with Hashimoto's thyroiditis underwent coeliac serological tests (antigliadins, transglutaminase and endomysium antibodies) and HLA-DQ typing. Small intestinal biopsy was performed when any of coeliac serological tests was positive. On the other hand, 184 patients with coeliac disease were subjected to thyroid biochemical (thyroid stimulating hormone and free thyroxine) and thyroid serological tests (thyroglobulin and thyroid peroxidase antibodies).RESULTS Of 104 patients with Hashimoto's thyroiditis, sixteen (15%) were positive for coeliac serology and five patients with documented villous atrophy were diagnosed with coeliac disease (4.8%; 95% CI 0.7-8.9). HLA-DQ2 (and/or -DQ8) was present in all the five and 53 patients with Hashimoto's thyroiditis (50%; 95% CI 43-62). Of 184 patients with coeliac disease, 39 (21%) were positive for thyroid serology. Based on thyroid biochemistry, the 39 patients were subclassified into euthyroidism in ten (5%; 95% CI 2-9), subclinicalhypothyroidism in seven (3.8%; 95% CI 1.8-7.6), and overt hypothyroidism (Hashimoto's thyroiditis) in 22 (12%; 95% CI 8-16). Moreover, four patients with coeliac disease had Graves' disease (2%; 95% CI 0.8-5) and one patient had post-partum thyroiditis.CONCLUSION The data from a Dutch population confirm the association between Hashimoto's thyroiditis and coeliac disease. Screening patients with Hashimoto's thyroiditis for coeliac disease and vice versa is recom mended. |
| Keywords: | Autoimmune disease Coeliac disease Hashimoto's thyroiditis |
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