乙肝病毒基因经生殖细胞垂直传递研究进展

乙型肝炎是危害人类健康的全球性疾病.大量研究表明,乙肝病毒(HBV)基因能够整合到人精子基因组中;携带HBV的人精子能正常地完成受精过程;受精后,由人精子带人胚胎细胞中的HBV基因能够复制和表达.它可能造成的严重后果是:①成为HBV经生殖细胞垂直传播新途径;②HBV基因整合到宿主配子基因组可增加配子染色体的不稳定性,进而诱发配子染色体畸变,导致流产、死产和出生缺陷率增加;③随着胚胎发育和个体生长,潜藏在宿主基因组中的HBV基因有可能增加肝细胞肿瘤发生的风险.

Transmission of HBV Gene via Germ Line

Hepatitis B is a public health problem worldwide.The recent studies have demonstrated that HBV DNA is able to integrate into human sperm genome and human sperms carrying HBV genes ale able to complete fertilization normally.After the fertilization,the sperm-mediated HBV genes ale able to replicate themselves and to express their functions at mRNA and protein levels in early embryonic cells,which may cause the severe outcomes including:①becoming a new transmission of HBV via germ line;②increasing the rate of abortion,stillbirth and birth defects resulted from host gamete chromosomal abberrations induced by integration of HBV DNA;③enhancing the risk of hepatocellular tumorigenesis induced by integrated HBV gene in host genome.