| 蛋白质组学在骨质疏松症中的应用 |
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| 引用本文： | 张世阳,高海青. 蛋白质组学在骨质疏松症中的应用[J]. 中国骨质疏松杂志, 2012, 18(3): 291-294 |
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| 作者姓名： | 张世阳 高海青 |
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| 作者单位： | 1. 230001 合肥,安徽医科大学附属省立医院,安徽省立医院老年病科
2. 250012 济南,山东大学齐鲁医院老年病科,山东省心血管病蛋白质组学重点实验室 |
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| 摘 要： | 蛋白质组学是继基因组学后提出的新兴学科。它以组织或细胞的全部蛋白质结构与功能为研究对象。近年来蛋白质组学技术飞速发展并已得到广泛应用。蛋白质组学在成骨细胞代谢、破骨细胞代谢以及骨质疏松症动物模型的研究中取得较大进展,从而在探讨骨质疏松症的发生机制,提供其早期诊断标志物的筛选以及寻找其治疗药物靶标等方面发挥了重要作用。
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| 关 键 词： | 蛋白质组学 质谱 骨质疏松症 成骨细胞 破骨细胞 |
The application of proteomics in osteoporosis |
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| Zhang Shiyang and Gao Haiqing. The application of proteomics in osteoporosis[J]. Chinese Journal of Osteoporosis, 2012, 18(3): 291-294 |
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| Authors: | Zhang Shiyang and Gao Haiqing |
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| Affiliation: | .Anhui Medical University,Anhui Provincial Hospital,Hefei 230001,China |
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| Abstract: | Proteomics is a new emerging science after genomics.The research subjects of proteomics include the structure and function of entire proteins in tissues or cells.Currently the proteomic technology has been developed and used widely.The applications of proteomics in osteoblasts metabolism,osteoclasts metabolism,and animal models of osteoporosis have also been developed significantly.So the proteomics has played a crucial role in exploring the mechanism of osteoporosis,in selecting new biomarkers for early diagnosis,and in identifying the pharmatheutical targets. |
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| Keywords: | Proteomics Mass spectrometry Osteoporosis Osteoblasts Osteoclasts |
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