| 格列喹酮滴丸及其片剂在体外的溶出度比较 |
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| 引用本文： | 向柏,敦洁宁,潘振华,王静,方瑜,齐晓丹,杜青,曹德英. 格列喹酮滴丸及其片剂在体外的溶出度比较[J]. 华西药学杂志, 2008, 23(3) |
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| 作者姓名： | 向柏 敦洁宁 潘振华 王静 方瑜 齐晓丹 杜青 曹德英 |
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| 作者单位： | 河北医科大学药学院,河北,石家庄,050017;河北医科大学药学院,河北,石家庄,050017;河北医科大学药学院,河北,石家庄,050017;河北医科大学药学院,河北,石家庄,050017;河北医科大学药学院,河北,石家庄,050017;河北医科大学药学院,河北,石家庄,050017;河北医科大学药学院,河北,石家庄,050017;河北医科大学药学院,河北,石家庄,050017 |
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| 摘 要： | 目的比较自制格列喹酮滴丸和市售片剂的体外释放特性。方法参考《中国药典》2005年版方法,进行自制滴丸和片剂的溶出度试验,结合紫外-分光光度法求算累积溶出百分率。结果滴丸在45 m in时的累积溶出百分率为95.29%,市售片剂为90.36%,两制剂的T50和Td有极显著性差异(P<0.01)。结论自制滴丸溶出快于片剂,且更完全。
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| 关 键 词： | 格列喹酮 溶出度 紫外分光光度法 |
Comparison of dissolution in vitro of Gliquidone dropping pill and its tablet |
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| XIANG Bai,DUN Jie-ning,PAN Zhen-hua,WANG Jing,FANG Yu,QI Xiao-dan,DU Qing,CAO De-ying. Comparison of dissolution in vitro of Gliquidone dropping pill and its tablet[J]. West China Journal of Pharmaceutical Sciences, 2008, 23(3) |
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| Authors: | XIANG Bai DUN Jie-ning PAN Zhen-hua WANG Jing FANG Yu QI Xiao-dan DU Qing CAO De-ying |
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| Abstract: | OBJECTIVE To investigate Gliquidone release in vitro of the self-made dropping pill and commercial tablet.METHODS The dissolution experiments of dropping pill and tablet were carried out according to experimental condition of dissolution rate test of China Pharmacopoeia(2005 version)by UV spectrophotometry.RESULTS The accumulated drug dissolution of Gliquidone dropping pill reached 95.29% at 45 min while the tablet was 90.36%.T50,Td of the two preparations showed significant difference(P<0.01).CONCLUSION The dropping pill was superior in the dissolution rate than that of tablet,which was worthy of further research and developing. |
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| Keywords: | Gliquidone Dissolution UV spectrophotometry |
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