The Role of Liver-Directed Therapy in Metastatic Colorectal Cancer |
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Authors: | Hon Lyn Tan Matilda Lee Balamurugan A. Vellayappan Wee Thong Neo Wei Peng Yong |
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Affiliation: | 1.Department of Haematology-Oncology,National University Cancer Institute, Singapore (NCIS), National University Health System,Singapore,Singapore;2.Department of Radiation Oncology,National University Cancer Institute, Singapore (NCIS), National University Health System,Singapore,Singapore;3.Department of Diagnostic Imaging,National University Health System,Singapore,Singapore |
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Abstract: | Purpose of ReviewColorectal cancer liver metastasis is a major clinical problem, and surgical resection is the only potentially curative treatment. We seek to discuss various liver-directed therapy modalities and explore their roles in the evolving realm of treatment strategies for metastatic colorectal cancer.Recent FindingsClinical outcomes for patients with colorectal cancer liver metastases have improved as more patients undergo potentially curative resection and as the armamentarium of systemic treatment and liver-directed therapies continues to expand. Liver-directed therapies have been developed as adjuncts to improve resectability, employed in the adjuvant setting to potentially reduce local recurrence rates, and utilized in the palliative setting with the aim to improve overall survival.SummaryOngoing research is expected to validate the role of these evolving therapeutic options, and determine how best to sequence and when to apply these therapies. |
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