Use of Interleukin-1 Blockers in Pericardial and Cardiovascular Diseases |
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Authors: | Giacomo Emmi Maria Letizia Urban Massimo Imazio Marco Gattorno Silvia Maestroni Giuseppe Lopalco Luca Cantarini Domenico Prisco Antonio Brucato |
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Institution: | 1.Department of Experimental and Clinical Medicine,University of Firenze,Florence,Italy;2.Nephrology Unit,University Hospital of Parma,Parma,Italy;3.University Cardiology, Cardiovascular and Thoracic Department,AOU Città della Salute e della Scienza of Torino,Turin,Italy;4.Clinic of Pediatrics and Rheumatology, Unit of Autoinflammatory Diseases and Immunodeficiencies,“G. Gaslini” Institute,Genoa,Italy;5.Internal Medicine,Ospedale Papa Giovanni XXIII,Bergamo,Italy;6.Department of Emergency and Organ Transplantation, Rheumatology Unit,Bari,Italy;7.Research Center of Systemic Autoinflammatory Diseases, Beh?et’s Disease Clinic and Rheumatology-Ophthalmology Collaborative Uveitis Center,University of Siena,Siena,Italy |
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Abstract: | Purpose of ReviewThis review aims to summarize the role of the interleukin-1 (IL-1) blocking agents in cardiovascular diseases, briefly describing the pathogenetic rationale and the most relevant clinical studies.Recent FindingsIL-1 is a pivotal cytokine of the innate immune system. Anti-IL-1 agents are currently used for the treatment of several autoimmune and autoinflammatory conditions. Recently, the role of IL-1 has also emerged in cardiovascular diseases. Indeed, two recent randomized controlled trials have shown that the IL-1 receptor antagonist anakinra is effective for the treatment of idiopathic recurrent pericarditis and the IL-1β blocking agent canakinumab is effective in reducing myocardial infarction in people at risk. Interestingly, interfering with IL-1 has proved to be also effective in other cardiovascular manifestations, such as myocarditis, arrhythmias, and heart failure.SummaryBlocking the IL-1 pathway is a possible new therapeutic strategy, potentially leading to innovative therapies in many acute and chronic cardiovascular diseases. |
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