| 四氢帕马汀对大鼠海马缺血再灌注损伤保护作用 |
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| 引用本文： | 闵清,吴基良,刘超,舒思洁. 四氢帕马汀对大鼠海马缺血再灌注损伤保护作用[J]. 医药导报, 2001, 20(5): 284-285 |
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| 作者姓名： | 闵清 吴基良 刘超 舒思洁 |
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| 作者单位： | 湖北省咸宁医学院药理学教研室, |
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| 摘 要： | 目的：研究四氢帕马汀（THP）对大鼠海马缺血再灌注损伤的保护作用。方法：利用结扎颈总动脉造成大鼠急性脑缺血再灌注模型，观察THP对大鼠海马缺血再灌注损伤的保护作用。结果：THP能使脑缺血再灌注过程中海马组织超氧化物歧化酶（SOD）活力（P＜0．01）和谷胱甘肽过氧化物酶（GSHPx)活力明显升高（P＜0．05），脂质过氧化产物丙二醛（MDA）明显下降（P＜0．01）；同时使细胞膜上Na^ -K^ -ATP酶和Ca^2 -Mg^2 -ATP酶活力升高（P＜0．05）。结论：THP对脑缺血再灌注损伤有保护作用。
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| 关 键 词： | 脑缺血 再灌注损伤 四氢帕马汀 保护作用 实验研究 |
| 文章编号： | 1004-0781(2001)05-0284-02 |
| 修稿时间： | 2000-12-07 |
The Protective Effects ofTetrahydropalmatine against Hippocamp Lesion Induced by Ischemia |
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| MIN Qing,WU Ji-liang,LIU Chao,SU Si-jie. The Protective Effects ofTetrahydropalmatine against Hippocamp Lesion Induced by Ischemia[J]. Herald of Medicine, 2001, 20(5): 284-285 |
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| Authors: | MIN Qing WU Ji-liang LIU Chao SU Si-jie |
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| Abstract: | Objective: To study the protective effects of tetrahydropalmatine (THP) against ischemia-reperfusion induced hippocamp lesion in rats. MethodS: A model of ischemia-reperfusion induced brain lesion was set up by ligation of common carotid arteria in rats, and the protective effects of THP was observed. Results: It was found that, with administration of THP, the activities of superoxide dismutase (SOD), glutathione peroxidase (GSHPx) and Na , K -ATPase as well as Ca 2 -ATPase were increased (P<0.05, respectively), while malondialehyde (MDA) was decreased to 42.5% (P<0.01) during brain ischemia-reperfusion. Conclusion:The results suggested that THP can protect the rat against ischemia-reperfusion induced brain lesion. |
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| Keywords: | Tetrahydropalmatine Hippocamp ischemia Reperfusion lesion |
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