| 心肌缺血预适应延迟相的研究进展 |
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| 引用本文： | 李春梅,张兴华. 心肌缺血预适应延迟相的研究进展[J]. 心血管病学进展, 2005, 26(5): 526-529 |
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| 作者姓名： | 李春梅 张兴华 |
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| 作者单位： | 山东大学,山东省立医院心内科,山东,济南,250021 |
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| 摘 要： | 心肌缺血预适应(ischemicpreconditioning,IPC)现象的发现,为心肌缺血再灌注损伤的预防开拓了一个新的研究领域。IPC分为快速相和延迟相,快速相IPC对心脏具有显著的保护作用,但这种保护作用在IPC后1~2h即消失。延迟相IPC在IPC后24h出现,心脏保护持续时间长,保护范围广。现对IPC延迟相的机制进展作一简要综述。
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| 关 键 词： | 缺血预适应 心肌缺血 延迟相 |
| 文章编号： | 1004-3934(2005)05-0526-04 |
| 收稿时间： | 2005-03-16 |
| 修稿时间： | 2005-06-09 |
Late Phase of Myocardial Ischemic Preconditioning |
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| LI Chun-mei,ZHANG Xing-hua. Late Phase of Myocardial Ischemic Preconditioning[J]. Advances in Cardiovascular Diseases, 2005, 26(5): 526-529 |
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| Authors: | LI Chun-mei ZHANG Xing-hua |
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| Affiliation: | ZengShu;ShenJiao |
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| Abstract: | The discovery of ischemic preconditioning(IPC) phenomenon has brought a new research field for the prevention and inhibition of myocardial ischemic reperfusion injury.IPC is classified into 2 distinct components:the classic early preconditioning and the delayed or late preconditioning.Early IPC has powerful cardioprotective effect,but it lasts only 1~2 hours.In contrast,the late phase of IPC becomes apparent 24 hours later and lasts 3 to 4 days.The purpose of this review is to summarize the current information regarding the process of late phase of IPC and the possible mechanism involved. |
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| Keywords: | Ischemic preconditioning Myocardial ischemia Late phase |
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