氟尿嘧啶对内镜逆行胰胆管造影术后胰腺炎的预防作用

目的：探讨５-氟尿嘧啶（５-FU）对内镜逆行胰胆管造影（ERCP）术后高淀粉酶血症及急性胰腺炎的预防作用。方法：将160例患者随机分为Ａ组（5-FU组）80例和Ｂ组（对照组）80例。Ａ组所用造影剂含有５-FU（76％泛影葡胺20 ml＋0.25％５-FU生理盐水30 ml），Ｂ组所用造影剂不含5-FU（76％泛影葡胺20 ml＋生理盐水30 ml），术前、术后6 h及24 h检测血清淀粉酶。结果：Ａ组有９例（11.25％）和Ｂ组有45例（56.25％）发生高淀粉酶血症，两组差异有显著意义（P<0.01）；Ａ组有2例（2.50％）和Ｂ组有8例（10.00％）发生急性胰腺炎，两组差异有显著意义（P<0.05）。结论：５-FU加入造影剂中能有效地预防ERCP术后因胰管显影所至的高淀粉酶血症及急性胰腺炎。

Preventive effect of 5-fluorouracil on post-ERCP pancreatitis

Objective To investigate the preventive effect of 5 fluorouracil (5 FU) on post ERCP (endoscopic retrograde cholangiopancreatography) hyperamy lasemia and pancreatitis. Methods One hundred and sixty patients who underwent ERCP were divided at random into 2 groups: group A ( n =80) was given meglumine diatrizoate with 5 FU; and group B ( n =80) was used contrast medium without 5 FU. Blood was drawn in each group the day before, 6 hours and 24 hours following ERCP for amylase. Results Post ERCP hyperamylasemia occurred in 9 patients in group A (11.25%) and 45 in B (56.25%) . The difference of both groups was notable. Pancreatitis ensued in 2 instances in group A (2.50%) and 8 in group B (10.00%). Their difference was significant. Conclusion 5 FU added in meglumine diatrizoate is helpful to prevent post ERCP hyperamylasemia and pancreatitis.