Early detection of premalignant lesions and oral cancer |
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Authors: | Steele Toby O Meyers Arlen |
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Institution: | a Department of Otolaryngology, Head and Neck Surgery, University of California Davis, 2521 Stockton Boulevard, Suite 7200, Sacramento, CA 95817, USA b Department of Otolaryngology, Dentistry, and Engineering, University of Colorado Denver, 12631 East 17th Avenue, B205 Aurora, CO 80045, USA |
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Abstract: | Cancers of the oral cavity account for approximately 3% of malignancies diagnosed annually in the United States. As with other upper aerodigestive tract cancers, 5-year survival rates for oral cavity cancers decrease with delayed diagnosis. Cancers of the oral cavity are thought to progress from premalignant/precancerous lesions, beginning as hyperplastic tissue and developing into invasive squamous cell carcinoma. Despite the general accessibility of the oral cavity during physical examination, many malignancies are not diagnosed until late stages of disease. To prevent malignant transformation of these oral precursor lesions, multiple screening and detection techniques have been developed to address this problem. |
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Keywords: | Oral cancer/carcinoma Oral premalignant lesions Optical detection technology Spectroscopy Optical coherence tomography Oral cancer screening |
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