| 丙型肝炎病毒载量与基因型和抗病毒疗效的关系研究 |
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| 引用本文： | 周友乾,尹凤鸣,冯经华.丙型肝炎病毒载量与基因型和抗病毒疗效的关系研究[J].实用肝脏病杂志,2011,14(5):340-343. |
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| 作者姓名： | 周友乾 尹凤鸣 冯经华 |
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| 作者单位： | 解放军第169中心医院感染病科,湖南省衡阳市,421002 |
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| 摘 要： | 目的探讨丙型肝炎患者血清HCV RNA载量与基因型的关系及其对抗病毒治疗疗效的影响。方法113例慢性丙型肝炎患者接受聚乙二醇干扰素联合利巴韦林抗病毒治疗。采用实时荧光定量PCR法检测血清HCV RNA载量,应用CE1区测序遗传树比对分析法检测HCV基因型。结果 113例患者分别感染1b、2a、3a、3b和6a共5种基因亚型,其HCV RNA载量（lgcopies/ml）分别为6.6973±1.19245、6.0824±1.68603、6.8393±1.03400、6.5533±1.29577和7.1503±1.16115,经单因素方差分析无明显统计学差异（P=0.166）;治疗前高血清HCV RNA载量者（≥107copies/ml）与低HCV RNA载量者（〈107copies/ml）完成治疗后获得SVR的比例,无论在所有患者（76.4%对75.9%,P=0.950）,还是在HCV1型（66.7%对60.0%,P=0.641）或非1型感染者（82.4%对87.9%,P=0.526）中均无统计学差异。结论治疗前血清HCV RNA载量与HCV基因型无关,血清HCV RNA载量对聚乙二醇干扰素联合利巴韦林抗病毒的疗效无明显影响。
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| 关 键 词： | 慢性丙型肝炎 HCVRNA 基因型 聚乙二醇干扰素 |
The relationship of HCV RNA levels to HCV genotypes as well as to responses to pegylated interferon and ribavirin therapy in patients with chronic hepatitis C |
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| ZHOU Youqian,YIN Fengming,FENG Jinghua.The relationship of HCV RNA levels to HCV genotypes as well as to responses to pegylated interferon and ribavirin therapy in patients with chronic hepatitis C[J].Journal of Clinical Hepatology,2011,14(5):340-343. |
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| Authors: | ZHOU Youqian YIN Fengming FENG Jinghua |
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| Institution: | ZHOU Youqian,YIN Fengming,FENG Jinghua.Department of Infectious Diseases,the 169th Hospital,Hengyang 421002,Hunan Province |
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| Abstract: | |
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| Keywords: | Hepatitis C Quantitative PCR Genotypes Pegylated interferon |
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