血清胆红素与甲状腺激素在糖尿病患者中的变化及意义

目的探讨2型糖尿病（T2DM）患者血清胆红素和甲状腺激素水平的变化及临床意义。方法检测87例T2DM患者和45例健康人血清胆红素和血清甲状腺激素。结果 T2DM患者FT3和IBIL水平分别为2.6±1.1pmol/L和5.0±2.8μmol/L,显著低于正常对照组的4.8±1.0pmol/L和8.8±2.6μmol/L（P〈0.05）;血糖控制差的患者FT3和IBIL水平较低（P〈0.05）;轻症糖尿病组FT3和IBIL水平分别为3.03±1.21pmol/L和7.51±3.17μmol/L,而重症组治疗前分别为1.91±0.86pmol/L和6.25±2.85μmol/L,治疗后为3.55±1.29pmol/L和8.11±3.06μmol/L。结论 FT3和IBIL水平变化与T2DM病情密切相关,可为临床诊治提供参考依据。

Changes of serum bilirubin and thyroid hormones in patients with diabetes mellitus type 2

Objective To investigate the clinical significance of serum bilirubin and thyroid hormone levels in patients with diabetes mellitus type 2(T2DM).Methods Blood from 87 patients with T2DM and 45 normal persons were tested the level of serum bilirubin and thyroid hormones.Results The FT3 and IBIL levels in T2DM were 2.6±1.1pmol/L and 5.0±2.8μmol/L,and in normal control group were 4.8±1.0pmol/L and 8.8±2.6μmol/L,respectively;the FT3 levels in the poor glycemic control group,bad glycemic control group and normal control group were 3.88±0.67 pmol/L,3.16±0.84 pmol/L and 4.38±0.51pmol/L,and the IBIL levels were 7.25±4.38μmol/L,5.93±2.97μmol/L and 8.56±3.32μmol/L,respectively;The serum IBIL and FT3 levels in mild diabetes groups were 3.03±1.21pmol/L and 7.51±3.17μmol/L,in severe groups were 1.91±0.86pmol/L and 6.25±2.85μmol/L;the serum IBIL and FT3 levels in severe groups after treatment were 3.55±1.29pmol/L and 8.11±3.06μmol/L.Conclusion The changes of FT3 and IBIL levels are closely related to the progress and curative effect in T2DM.