Matrix‐Metalloproteinase‐2 Predicts Arteriovenous Fistula Failure in Hemodialysis Patients |
| |
Authors: | Dacian C?lin Tirinescu Ciprian Tomuleasa Laura Pop Cosmina Ioana Bondor Dan ?tefan Vl?du?iu Ioan Mihai Pa?iu Crina Claudia Rusu Diana Tania Moldovan Alina Potra Ina Maria Kacsó |
| |
Institution: | 1. Department of Nephrology and Dialysis, ?Iuliu Ha?ieganu” University of Medicine and Pharmacy Cluj, Cluj‐Napoca, Romania;2. Department of Haemathology, ?Iuliu Ha?ieganu” University of Medicine and Pharmacy Cluj, Cluj‐Napoca, Romania;3. Research Center for Functional Genomic, Biomedicine and Translational Medicine, ?Iuliu Ha?ieganu” University of Medicine and Pharmacy Cluj, Cluj‐Napoca, Romania;4. Department of Informatics and Biostatistics, ?Iuliu Ha?ieganu” University of Medicine and Pharmacy Cluj, Cluj‐Napoca, Romania;5. Nefromed Dialysis Centers, Cluj‐Napoca, Romania |
| |
Abstract: | In hemodialysis patients the principal cause of arteriovenous fistula dysfunction is stenosis. Matrix‐metalloproteinase‐2 is implicated in the pathophysiological mechanism of stenosis development. Our study tried to assess the clinical impact of this protease on arteriovenous fistula survival. Seventy‐nine prevalent dialysis patients with functional arteriovenous fistulas were included in the study. The presence of stenosis and the serum levels of matrix‐metalloproteinase‐2 were determined at the beginning of the study. The patency of the arteriovenous fistulas was followed‐ up for two years. In multivariate regression; matrix‐metalloproteinase‐2 was a significant predictor of vascular access loss (HR = 1.104, 95%CI 1.033–1.179, P = 0.003). Patients with a level of matrix‐metalloproteinase‐2 lower than 50 ng/mL had a better survival of the arteriovenous fistulas. Matrix‐metalloproteinase‐2 was an even stronger predictor of fistula failure in the stenosis group (HR = 1.076, 95%CI 1.027–1.127, P = 0.002). In our study matrix‐metalloproteinase‐2 has a predictive value for arteriovenous fistula failure. |
| |
Keywords: | Arteriovenous fistula Failure Dialysis Matrix metalloproteinase Stenosis |
|
|