p27^kip1、Skp2在乳腺癌病变中的表达及其意义

①目的 探讨p27^kip1、Skp2蛋白在乳腺癌的发生、增殖厦转移扩散过程中的作用及其相互关系。②方法 用免疫组织化学EnVision法检测100例乳腺癌、30例乳腺增生症厦30例癌旁乳腺组织标本中p27^kip1、Skp2蛋白的表达。③结果 p27^kip1、Skp2蛋白在癌旁组、增生组、乳腺癌组的表达分别为100％、93．33％和56．00％，相互比较均有显著性差异（P〈0.01）。p27^kip1蛋白与Skp2蛋白在乳腺癌组中的表达呈负相关。④结论 在乳腺癌组织中，Skp2常呈高表达。p27^kip1则低表达，说明Skp2与p27^kip1的表达对肿瘤的诊断具有重要意义。

The expression and significance of p27^kip1,Skp2 in breast cancer

Obective To investigate the effect and relationships of p27~(kip1),Skp2 in the occurrence,malignant grow,proliferation and diffusion of breast cancer by testing the expression of p27~(kip1) protein,Skp2 protein in breast cancer.Methods The expression of p27~(kip1),Skp2 was detected in 100 cases of breast cancer,30 cases of hyperplasia mammary and 30 cases of neighboring non-cancerous tissue by using immunohisochemical EnVision.Results The expression of p27~(kip1) protein in the neighboring non-cancerous tissue,hyperplasic mammary and breast cancer group were 100%,93.33% and 56.00%,it showed a significant difference between breast cancer group and the other two groups(P<0.01).The positive rate of p27~(kip1) protein was 37.5% in the breast cancer with the lymph node metastasis and 68.33% without the lymph node metastasis.It showed a significant difference between two groups(P<0.01).The expression of Skp2 protein was correlated with clinical stages(P<0.05).There was negative relationship between the expression of p27~(kip1) protein and Skp2 protein in breart.Conclusion The expression of Skp2 protein in breast cancer was up-regulation and p27~(kip1) was down-regulation.Expression of cancer Skp2 and p27~(kip1) were important significance in cancer dignosis.