死腔测定在支气管哮喘中应用价值的研究

目的 探讨容积二氧化碳图(volumetric capnography,VCap)技术死腔测定在支气管哮喘(简称哮喘)中的应用价值及临床意义.方法 对52例急性发作期哮喘患者及35名健康志愿者的常规肺功能指标及Langley死腔(VDL)、Fowler死腔(VDF)、Wolff死腔(VDW)进行测定分析.结果 本研究显示:哮喘组中VDL、VDF及VDW均较对照组显著减小(P<0.01,0.01,0.01).相关分析显示:VDL、VDF和VDW分别与FEV1占预计值%、FEV1/FVC%、PEF占预计值%、FEF25占预计值%、FEF50占预计值%、FEF75占预计值%、MMEF占预计值%呈负相关(P<0.05),与RV占预计值%、TLC占预计值%、Rv/TLC%呈正相关(P<0.05).结论 VCap死腔测定患者易于配合,对哮喘的辅助诊断及进一步了解其病理生理改变具有一定的临床价值和意义.

Applied value of dead spaces measuring in bronchial asthma

Objective To investigate the applied value and implications of dead spaces from volumetric capnography(VCap)in bronchial asthma(asthma).Methods The ventilation and volume function together with series dead spaces,which include Langley dead space(VDL),Fowler dead space(VDF)and Wolff dead space(VDW) were measured in 52 patients with asthma exacerbation and 35 controls.Results Compared with healthy group,VDL,VDF and VDW in asthma group showed significant decrease(P<0.01,0.01,0.01).In asthma group,VDL,VDF and VDW were all negative correlated with FEVl%pred,FEV1/FVC%,PEF%pred,FEF25%pred,FEF50%pred,FEF75%pred and MMEF%pred(P<0.05).At the same time,they were positive correlated with RV.TLC and RV/TLC(P<0.05).Conclusions The dead spaces measurement of VCap is easy to be cooperated by patients.And it may have clinical value in diagnosing asthma.