| 镉、汞中毒性肾损伤尿中溶菌酶和碱性磷酸酶活性的变化 |
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| 引用本文： | 郭卫星,王翔朴.镉、汞中毒性肾损伤尿中溶菌酶和碱性磷酸酶活性的变化[J].中国药理学与毒理学杂志,1987(1). |
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| 作者姓名： | 郭卫星 王翔朴 |
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| 作者单位： | 湖南医学院环境医学研究室，湖南医学院环境医学研究室 长沙 410008，长沙 410008 |
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| 基金项目： | 中国科学院科学基金84(生)-342 |
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| 摘 要： | 在镉、汞亚急性中毒性肾损伤的过程中,尿中溶菌酶活性增高比尿蛋白、尿糖和肾小球滤过率的变化更敏感。尿中碱性磷酸酶活性增高,可能不适宜作为镉中毒性肾损伤的早期指标,但对于汞性肾损伤的早期诊断,具有一定的意义。
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| 关 键 词： | 金属 镉 汞 尿 溶菌酶 碱性磷酸酶 肾损伤 |
The changes of lysozyme and alkaline phosphatase in urine in cadmium and mercury poisoning renal damage |
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| GUQ Wei-xing,WANG Xiang-pu.The changes of lysozyme and alkaline phosphatase in urine in cadmium and mercury poisoning renal damage[J].Chinese Journal of Pharmacology and Toxicology,1987(1). |
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| Authors: | GUQ Wei-xing WANG Xiang-pu |
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| Abstract: | The relationship between the activity changes of urine lysozyme (U-LYS) and urine alkaline phosphatase (U-ALP) and those of urine protein, urine glucose, glomer-ular filtration rate(GFR)and othe rre-nal damage indications was observed on an animal model of cadmium(Cd) or mercury (Hg) poisoning renal damage. Cd-group (18 rats) and Hg-group (18 rats) were injected ip with 0.74mg Cd2+/(kg·d), and 0.74 mg Hg2+(kg·d) respectively for 45 day. Control group (9 rats) received same volume of normal saline. The results showed that the increase of U-LYSactivity was more sensitive than the changes of urine contents of protein and glucose and GFR in Cd-poison-ing or Hg-poisoning renal damage. The increase of U-ALP activity appeared earlier than other changes in Hg-poisoning renal damage.No similar apparent changes were found in Cd-group. Thus, it seemed that the increase of U-ALP activity can be used as an early indication for detection of Hg-poisoning renal damage. |
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| Keywords: | metals cadmium mercury urine muramidase alkaline phosphatase kidney injury |
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