| 幽门螺杆菌感染患者胃黏膜组织中8-羟-2-脱氧鸟苷的测定及意义 |
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| 引用本文： | 王建,沈建根. 幽门螺杆菌感染患者胃黏膜组织中8-羟-2-脱氧鸟苷的测定及意义[J]. 中国基层医药, 2006, 13(5): 707-708,i0001 |
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| 作者姓名： | 王建 沈建根 |
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| 作者单位： | 1. 310006,浙江省杭州,杭州市第一人民医院肿瘤内科
2. 浙江大学免疫学研究所 |
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| 基金项目： | 浙江省科技厅基金资助项目（011103015） |
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| 摘 要： | 目的检测胃黏膜组织8-羟-2-脱氧鸟苷（oh8dG）表达水平,试图从幽门螺杆菌（helicobacter pylori,Hp）致胃上皮DNA氧化损伤方面探讨Hp的致癌性.方法取Hp阳性和Hp阴性胃黏膜组织各50例,采用免疫组化法检测其oh8dG表达水平.结果免疫组化显示Hp阳性和Hp阴性胃黏膜组织之间的oh8dG表达水平差异有统计学意义（P＜0.01）.结论 Hp感染增加了胃黏膜组织oh8dG水平,DNA氧化损伤在Hp感染引发胃癌的过程中起重要作用.
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| 关 键 词： | 8-羟基-2 -脱氧鸟苷 螺杆菌感染 DNA |
| 收稿时间： | 2006-01-19 |
| 修稿时间： | 2006-01-19 |
The detection of oh8dG in Hp positive and Hp negative gastric tissue and its significance |
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| WANG Jian,SHEN Jian-gen. The detection of oh8dG in Hp positive and Hp negative gastric tissue and its significance[J]. Chinese Journal of Primary Medicine and Pharmacy, 2006, 13(5): 707-708,i0001 |
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| Authors: | WANG Jian SHEN Jian-gen |
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| Abstract: | Objective To detect the expression of oh8dG in gastric tissues and discuss the carcinogenicity of Hp.Methods oh8dG was detected with immunohistochemistry in Hp positive and Hp negative tissues.Results In immunohistochemistry,the positive rates of oh8dG expression in Hp positive and Hp negative tissues were 78% and 8%,respectively(P<0.01).Conclusion Hp infection increase oh8dG level in gastric mucosa and DNA oxidative damage play an important role in the process of gastric carcinogenesis by Hp infection. |
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| Keywords: | 8-hydroxy-2'-deoxyguanosine Helicobacter infections DNA |
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