维生素B6（VitB6）对姐妹染色单体互换（SCE）频率的影响

本文研究了维生素Ｂ６体外体内试验对ＳＣＥ频率的影响，体外试验不同剂量ＶｉｔＢ６诱发中国仓鼠肺细胞株细胞及人周血淋巴细胞的ＳＣＥ频率显著升高，但体内试验ＶｉｔＢ６诱导的小鼠骨髓细胞ＳＣＥ频率与对照组比较无显著性差别。看来ＶｉｔＢ６在体内不是致突变剂。

EFFECT OF VITB6 ON FREQUENCY OF SISTER CHROMATID EXCHANGE (SCE) IN VARIOUS CELLS BY USING IN VITRO AND IN VIVO ASSAY

The purpose of this paper is to study the effect of VitB 6 on frequency of sister chromatid exchange(SCE) in cells from human and animals by using in Vitro and in Vivo assay. In vitro assay, the frequency of SCE was markedly increased in both cells from human lymphocytes and the Chinese hamster lung cell line (CHL), which were exposed to the VitB 6 in various doses. A dose response was presented. But in Vivo assay, the statistic difference between the SCE rates of mouse bone marrow cells in test group and in that of control group was not observed. In Vivo assay, it seems that the VitB 6 may be not a muatgen.