| OF—3的致突变,致畸的研究 |
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| 引用本文： | 周立国,周谟炯.OF—3的致突变,致畸的研究[J].癌变．畸变．突变,1998,10(2):101-104. |
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| 作者姓名： | 周立国 周谟炯 |
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| 作者单位： | 同济医科大学药学院 |
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| 摘 要： | 报道ＯＦ－３对小鼠的急性毒性试验、微核试验，对大鼠骨髓染色体畸变及对大鼠的致畸试验的结果，小鼠经口ＬＤ５０为３．３０ｇ／ｋｇ。其剂量在０．１６－１．６５ｇ／ｋｇ的微核试验结果表明：各剂量组与阴性对照组的微核率比较，结果无显著意义（Ｐ〉０．０５）；０．３３－１．６５ｇ／ｋｇ剂量组对大鼠的骨髓染色体畸变也无明显影响；致畸试验中随剂量的增大，母鼠的增长越缓慢。同时，鼠胎的体重也明显低于阴性对照组。提示：
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| 关 键 词： | OF－3 微核试验 骨髓 染色体畸变 致畸试验 |
STUDIES ON THE MUTATION AND TERATOGENICITY OF OF 3 |
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| Zhou Liguo\ Zhou Mojiong\ Shao Xuexiwi\ Cheng Ling School of Pharmacy,Tongji Medical University,Wuhan.STUDIES ON THE MUTATION AND TERATOGENICITY OF OF 3[J].Carcinogenesis,Teratogenesis and Mutagenesis,1998,10(2):101-104. |
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| Authors: | Zhou Liguo\ Zhou Mojiong\ Shao Xuexiwi\ Cheng Ling School of Pharmacy Tongji Medical University Wuhan |
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| Institution: | Zhou Liguo\ Zhou Mojiong\ Shao Xuexiwi\ Cheng Ling School of Pharmacy,Tongji Medical University,Wuhan 430030 |
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| Abstract: | In this paper, the mutation and teratogenic effect of the OF 3 were investigated. The LD50 was determined as 3.3g/kg in mice by oral. The results indicated that the micronucleus rate was not significant difference (P>0.05) in dosage of 0.17-1.65/kg/day and the marrow chromosome aberration was negative in dosage of 0.03-0.17g/kg,but in teratogenic test, the weight of the female rats and its fetus were lighten with the dosage increasing, this result shows the OF 3 have toxic effect on fetus in long term administration. |
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| Keywords: | OF 3 animal experiment micronucleus marrow chromosome aberration teratogenic effect |
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