| Affiliation: | 1. Faculdade de Ciências Médicas de Minas Gerais, Hospital Universitário Ciências Médicas, Belo Horizonte, MG, Brazil;2. Isala Hospital, Princess Amalia Children''s Centre, Zwolle, The Netherlands;3. University Medical Centre and University of Groningen, UMCG Postgraduate School of Medicine, Groningen, The Netherlands;4. Universidade Federal de Minas Gerais (UFMG), Hospital das Clínicas, Unidade de Pneumologia Pediátrica, Belo Horizonte, MG, Brazil |
| Abstract: | ObjectiveThere is a scarcity of studies that assessed the association between adherence to combination therapy and asthma control in pediatric patients. The authors investigated the association between adherence to fluticasone propionate/salmeterol xinafoate combination-metered aerosol and the level of asthma control in children.MethodsThis was a prospective observational study of 84 patients aged 5–16 years with moderate persistent asthma, who remained uncontrolled despite the use of 1000 μg/day of inhaled nonextrafine-hydrofluoric alkane-beclomethasone dipropionate in the three months prior to study enrollment. Participants were prescribed two daily doses of FP (125 μg)/salmeterol xinafoate (25 μg) combination by metered aerosol/spacer for six months. Adherence rates were assessed using the device's dose counter after the 2nd, 4th, and 6th months of follow up. Asthma control was assessed using a simplified Global Initiative for Asthma 2014 Report classification.ResultsMean adherence rates after the second, fourth, and sixth months were 87.8%, 74.9%, and 62.1% respectively, for controlled asthma, and 71.7%, 56.0%, and 47.6% respectively, for uncontrolled asthma (all p-values ≤ 0.03). The proportion of children achieving asthma control increased to 42.9%, 67.9% and 89.3% after the 2nd, 4th and 6th months of follow-up, respectively (p ≤ 0.001).ConclusionAdherence rates between 87.8% in the 2nd month and 62.1% in the 6th month were strong determinants of asthma control. |
