高频超声评价长期饮酒者肱动脉内皮功能

目的探讨应用高频超声评价长期饮酒者肱动脉内皮功能变化的价值。方法将80例男性饮酒者分为3组：A组30例,每日饮白酒≥90g（即纯乙醇75ml）或啤酒1100～1650ml,3～5天/周,饮酒5～8年;B组25例,每日饮白酒≥90g（即纯乙醇75ml）或啤酒1100～1650ml,3～5天/周,饮酒9～20年;C组25例,每日饮白酒≥150g（即纯乙醇125ml）或啤酒≥2200ml,6～7天/周,饮酒≥10年。另选30名健康志愿者作为正常对照组（D组）。超声检测各组受试者肱动脉基础内径、反应性充血后内径并计算肱动脉内皮依赖性舒张功能（EDD）。结果与D组和A组比较,B组、C组的EDD显著减小;与B组比较,C组EDD显著减小;差异均有统计学意义（P均〈0.01）。A组与D组比较,差异无统计学意义（P〉0.05）。结论高频超声可以准确评估长期饮酒者肱动脉内皮功能的变化。

Evaluation on the brachial artery endothelial function of the long-term drinkers with high frequency ultrasound

Objective To evaluate the brachial artery endothelial function of the long-term drinkers by high frequency ultrasound.Methods Eighty chronic alcohol abusers were divided into 3 groups: Group A(n=30,consumed ≥90 g ethanol or 1100—1650 ml of beer daily for 5 to 8 years,3 to 5 days per week),Group B(n=25,consumed ≥90 g ethanol or 1100—1650 ml of beer daily for 9 to 20 years,3 to 5 days per week) and Group C(n=25,consumed ≥150 g ethanol or ≥2200 ml of beer daily for more than 10 years,6 to 7 days per week).Thirty healthy volunteers were enrolled as control group(Group D).High frequency ultrasound was applied to measure the diameter of the brachial artery during rest and reactive hyperemia as well as endothelium-dependent dilation(EDD).Results EDD was significantly lower in Group B and C than in Group A and D(P<0.01).Compared to Group B,EDD in Group C was significantly lower(all P<0.01).There was no statistical difference of EDD between Group A and D(P>0.05).Conclusion High frequency ultrasound can be used to accurately assess the brachial artery endothelial function of the long-term drinkers.