| 中国汉族人群14号染色体上五个STR的遗传多态分析 |
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| 引用本文： | 郭辰虹,龚瑶琴,陈丙玺,卢勇,魏农,邹雅群,刘晓军.中国汉族人群14号染色体上五个STR的遗传多态分析[J].中华医学遗传学杂志,2000,17(2):112-115. |
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| 作者姓名： | 郭辰虹 龚瑶琴 陈丙玺 卢勇 魏农 邹雅群 刘晓军 |
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| 作者单位： | 250012,济南,山东医科大学医学遗传学教研室 |
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| 基金项目： | 国家自然科学基金!(39870409) |
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| 摘 要： | 目的 分析中国汉族人群１４号染色体上５个ＳＴＲ的基因及基因型分布情况。方法 采用ＰＣＲ扩增技术和聚丙烯酰胺凝胶电泳方法，对５０名中国汉族人１４号染色体上Ｄ１４Ｓ７４２，Ｄ１４Ｓ３０６，Ｄ１４Ｓ６０６，Ｄ１４Ｓ６１７和Ｄ１４Ｓ６１１位点的遗传多态性进行分析。结果 在Ｄ１４Ｓ７４２位点，共观察到５个等位片段和１３种基因型，最常见的等位片段为４０７ｂｐ片段，频率为０．３１；Ｄ１４Ｓ３０６位点，共观察到５
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| 关 键 词： | 短串联重复序列 遗传多态性 STR 汉族 |
| 修稿时间： | 1999-01-29 |
Genetic polymorphism of 5 STR loci on chromosome 14 in Chinese Han |
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| GUO Chenhong,GONG Yaoqin,CHEN Bingxi,LU Yong,WEI Nong,ZOU Yaqun,LIU Xiaojun.Genetic polymorphism of 5 STR loci on chromosome 14 in Chinese Han[J].Chinese Journal of Medical Genetics,2000,17(2):112-115. |
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| Authors: | GUO Chenhong GONG Yaoqin CHEN Bingxi LU Yong WEI Nong ZOU Yaqun LIU Xiaojun |
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| Institution: | Department of Medical Genetics, Shandong Medical University, Jinan, Shandong, 250012 P.R.China. chenhongguo@mailcity.com. |
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| Abstract: | Objective To understand the distribution of genes and genotypes of 5 STR loci on chromosome 14 in Chinese Han. Methods PCR and polyacrylamide gel electrophoresis were used to analyze the polymorphism of 5 STR loci (D14S742, D14S306,D14S606, D14S617,D14S611) on chromosome 14 in Chinese Han. Results 5 alleles and 13 genotypes,5 alleles and 13 genotypes, 6 alleles and 13 genotypes,9 alleles and 21 genotypes, and 6 alleles and 13 genotypes were observed at D14S742, D14S306, D14S606, D14S617 and D14S611,respectively.The frequencies of the most common allele at these five loci were 0.31,0.31, 0.47, 0.35 and 0.29 respectively. Conclusion These five loci are highly polymorphic in Chinese Han and their allele distribution is in good agreement with Hardy Weinberg equilibrium. |
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| Keywords: | short tandem repeat genetic polymorphism Hardy Weinberg equilibrium |
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