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| 利多卡因抑制颅脑损伤后继发性脑损害的临床研究 | |
| 引用本文： | 刘立良,黎建明,张日华,魏建功,曹作为,刘道斌,彭贵华,刘和录. 利多卡因抑制颅脑损伤后继发性脑损害的临床研究[J]. 中国临床神经外科杂志, 2003, 8(1): 22-24 |
| 作者姓名： | 刘立良 黎建明 张日华 魏建功 曹作为 刘道斌 彭贵华 刘和录 |
| 作者单位： | 1. 深圳市沙井人民医院神经外科,广东,深圳,518104 2. 海口市人民医院神经外科,海南,海口.570208 3. 中南大学附属湘雅医院检验科,湖南,长沙,410008 4. 深圳市沙井人民医院检验科,广东,深圳,518104 |
| 摘 要： | 目的：寻找能控制脑外伤后继发性脑损害的发生发展的药物或方法。方法：53例脑外伤病人，随机分为治疗组（A）、对照组（B），A组25例持续应用利多卡因七天。结果：A组25例血中儿茶酚胺，肌酐，血糖以及脑脊液中乳酸脱氢酶，磷酸肌酸激酶，苷露醇和速尿的用量，应激性溃疡发生率，死亡植物生存率均明显低于对照组，结论：利多卡因能抑制颅脑损伤后继发性脑损害的发生发展。 |
| 关 键 词： | 颅脑损伤 继发性脑损害 治疗 利多卡因 |
| 文章编号： | 1009-153X(2003)01-0022-03 |
| 修稿时间： | 2001-12-30 |
Clinical Study of Effects of Lidocaine on Cerebral Damage Secondary to Brain Trauma |
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| LIU Li-liang ,LI Jian-ming,ZHANG Ri-hua,et al.. Clinical Study of Effects of Lidocaine on Cerebral Damage Secondary to Brain Trauma[J]. Chinese Journal of Clinical Neurosurgery, 2003, 8(1): 22-24 | |
| Authors: | LIU Li-liang LI Jian-ming ZHANG Ri-hua et al. |
| Affiliation: | LIU Li-liang *,LI Jian-ming,ZHANG Ri-hua,et al. * Department of Neurosurgery,Shajing People's Hospital,Guangdong Shenzhen518104,China |
| Abstract: | Objective To look for drugs or methods to control developing of the cerebral damage secondary to brain trauma.Methods All53patients with brain trauma (with or without intracrainal hematomas,GCS<11)were randomly divided into the Lidocaine-treatment group(25cases)and the control group(28cases).Lidocaine was intravenously administrated continously for7days during which the blood pressure,pulse,respiration,ECG and SPo 2 were determined in all the patients.The levels of blood catecholamine(CA),cretonne(Cr)and Glucose(Glu)and CSF lactatedehydrogenase(LDH)and creatinephosphokinase(CK)were examined.Results The levels of blood CA,Cr and Glu,and CSF LDH and CK,the amount of administrated mannitol and lasix,the occurrence rate of stress ulcer,and the rates of death and vegetable survival in the treatment group were significantly lower than those in the control group.Conclusion Lidocane has inhibitory effects on the cerebral damage secondary to brain trauma.[ |
| Keywords: | Brain trauma Secondary damage Therapy Lidocaine |
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