| 雷耐酸锶在骨吸收中的作用 |
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| 引用本文： | 万英明,王景云,王为民,李婉. 雷耐酸锶在骨吸收中的作用[J]. 中国组织工程研究与临床康复, 2008, 12(50): 9993-9996 |
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| 作者姓名： | 万英明 王景云 王为民 李婉 |
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| 作者单位： | 1. 吉林大学口腔医学院修复科,吉林省长春市,130041
2. 吉林油田总医院口腔科,吉林省松原市,138006 |
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| 摘 要： | 大多数抗骨质疏松药物只能抑制骨吸收而不能促进骨的形成。雷奈酸锶是目前为止唯一具有“双重作用”的抗骨质疏松药物，既能抑制骨的吸收又能促进骨的形成。通过检索文献，文章从药理实验、临床研究及作用机制3方面总结骨吸收中雷奈酸锶的作用和研究进展。
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| 关 键 词： | 雷奈酸锶 骨吸收 骨形成 综述 |
Effect of strontium ranelate on bone resorption |
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| Wan Ying-ming,Wang Jing-yun,Wang Wei-min,Li Wan. Effect of strontium ranelate on bone resorption[J]. Journal of Clinical Rehabilitative Tissue Engineering Research, 2008, 12(50): 9993-9996 |
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| Authors: | Wan Ying-ming Wang Jing-yun Wang Wei-min Li Wan |
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| Abstract: | BACKGROUND: Most of anti-osteoporosis drugs can only inhibit bone resorption, but can not improve the bone formation. So far, Strontium ranelate is the only anti-osteoporosis drug that has a dual effect on bone resorption and bone formation. Through the retrieval of related studies, the present review article evaluates the current understanding of strontium ranelate effects on bone resorption based on the pharmacologic experiments, clinical studies, action mechanisms. Recombinant human bone morphogenetic protein-2 (rhBMP-2) has been widely used on clinic; however, there are still few reports addressing rhBMP-2-induced osteogenesis in intervertebral disc. |
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