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Prostaglandin F2alpha increases the sensitivity of the contractile proteins to Ca2+ in human myometrium |
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| Authors: | Woodcock Nicola A Taylor Colin W Thornton Steven |
| Affiliation: | a Department of Biological Sciences, University of Warwick, Coventry, UK b Department of Pharmacology, University of Cambridge, Cambridge, UK c The Medical School, University of Warwick, Coventry, UK; University Hospitals of Coventry and Warwickshire, Coventry, UK |
| Abstract: | It is not known whether agonists (other than oxytocin) increase the contractile protein sensitivity to intracellular calcium ([Ca2+]i) in human myometrium. We determined the calcium-tension relationship in the presence and absence of prostaglandin F2alpha (PGF2alpha). PGF2alpha increased the calcium sensitivity during both the contractile (rising) and relaxation (falling) phases of a contraction. |
| Keywords: | Myometrial contraction PGF2α Ca2+-sensitivity |
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