HEPATITIS C VIRUS AND ESSENTIAL MIXED CRYOGLOBULINAEMIA |
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| Authors: | CACOUB, P. MUSSET, L. FABIANI, F. LUNEL PERRIN, M. LEGER, J.-M. HUONG DU, L THI WECHSLER, B. BLETRY, O. OPOLON, P. HURAUX, J.-M. PIETTE, J.-C. GODEAU, P. |
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| Affiliation: | *Department of Internal Medicine 75013 Paris France
!["{dagger}"]("/math/dagger.gif") Immunochemical Laboratory 75013 Paris France
!["{ddagger}"]("/math/Dagger.gif") Virological Laboratory 75013 Paris France
!["§"]("/math/sect.gif") Department of Neurology 75013 Paris France
¶Liver and Gastrointestinal Department, Hôpital Piiié-Salpëtrière, 83 Bd de l'Hôpital 75013 Paris France |
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| Abstract: | Clinical and laboratory evidence of liver involvement are frequentlyfound in essential mixed cryoglobulinaemia (EMC). We lookedfor evidence of hepatitis C virus (HCV) infection in 37 patientswith EMC. Anti-HCV antibodies (Ab) were found in 16/37 (43%)patients with EMC using the ELISA 2 test and the RIBA 2 test.The 16 anti-HCV-Ab positive patients (group 1) were comparedto the 21 anti-HCV-Ab negative patients (group 2). Group 1 patientshad more frequent cutaneous involvement (P = 0.02), clinical,biological and histologic hepatic involvement (P<0.01), higherserum cryoglobulin and lower CH50 levels (P<0.001). Serumhepatitis B virus markers were infrequent in both groups andno patient from either group had detectable serum HBV DNA. Thesepreliminary results suggest that HCV may be another cause ofmixed cryoglobulinaemia. KEY WORDS: Hepatitis C virus, Cryoglobulinaemia |
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