| MUC5AC在人类鼻息肉及下鼻甲黏膜上皮的表达 |
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| 引用本文： | 吕海丽,郭永清,董震.MUC5AC在人类鼻息肉及下鼻甲黏膜上皮的表达[J].临床耳鼻咽喉头颈外科杂志,2004,18(11):649-650,i003. |
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| 作者姓名： | 吕海丽 郭永清 董震 |
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| 作者单位： | 1. 吉林大学中日联谊医院耳鼻咽喉-头颈外科,长春,130021
2. 厦门中山医院耳鼻咽喉科 |
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| 摘 要： | 目的 :探讨MUC5AC与鼻息肉及慢性肥厚性鼻炎黏液过量分泌的关系。方法 :免疫组织化学ABC法检测 2 7例鼻息肉、19例慢性肥厚性鼻炎下鼻甲及 9例正常下鼻甲黏膜上皮MUC5AC的表达。结果 :鼻息肉黏膜上皮及慢性肥厚性鼻炎下鼻甲黏膜上皮MUC5AC阳性细胞表达率明显高于正常下鼻甲黏膜上皮 (P <0 .0 5 ) ,且MUC5AC阳性表达细胞主要为杯状细胞。结论 :MUC5AC在鼻息肉及慢性肥厚性鼻炎下鼻甲黏膜上皮呈高表达 ,且阳性细胞为杯状细胞 ,表明MUC5AC确实对鼻息肉及慢性肥厚性鼻炎的黏液过量分泌起了一定作用。
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| 关 键 词： | 粘蛋白类 基因 MUC5AC 鼻息肉 |
| 文章编号： | 1001-1781(2004)11-0649-02 |
| 修稿时间： | 2003年9月5日 |
Expression of MUC5AC in human nasal polyp and inferior turbinate epithelium |
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| Haili Lü,Yongqing Guo,Zhen Dong.Expression of MUC5AC in human nasal polyp and inferior turbinate epithelium[J].Journal of Clinical Otorhinolaryngology,2004,18(11):649-650,i003. |
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| Authors: | Haili Lü Yongqing Guo Zhen Dong |
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| Institution: | Department of Otolaryngology-Head and Neck Surgery, China-Japan Union Hospital of Jilin University, Changchun, 130031, China. |
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| Abstract: | OBJECTIVE: To examine the expression of MUC5AC in human nasal polyp and inferior turbinate epithelium, to evaluate the relationship between MUC5AC and the increased mucous secretions in polyps and chronic hypertrophy rhinitis. METHOD: With immunohistochemistry ABC and HE dyeing, twenty-seven polyps, nineteen chronic hypertrophy rhinitis and eleven normal inferior turbinates epithelium were applied to this study. RESULT: The number of MUC5AC+ cells in nasal polyps and chronic hypertrophy rhinitis was significantly bigger than that in normal inferior turbinates (P < 0.05), and the MUC5AC+ cells were mainly concentrate on the goblet cells. CONCLUSION: MUC5AC is highly expressed in epithelium of human polyps and chronic hypertrophy rhinitis inferior turbinates, and MUC5AC takes part in increasing secretion in polyps and chronic hypertrophy rhinitis. |
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| Keywords: | Mucins Gene MUC5AC Nasal polyp |
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