| 安定在体外对大鼠胆碱酯酶和红细胞膜稳定性的作用 |
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| 引用本文： | 刘志毅,张才丽,等.安定在体外对大鼠胆碱酯酶和红细胞膜稳定性的作用[J].中国药学,1995,4(1):17-21. |
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| 作者姓名： | 刘志毅 张才丽 |
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| 作者单位： | [1]河南医科大学临床药理教研室，郑州450052 [2]天津医学院药理教研室，天津300190 |
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| 摘 要： | 结果显示安定能抑制大鼠血浆、红细胞、纹状体和膈肌胆碱酯酶活性，此作用呈浓度增高而增强的趋势。还证实安定是真性胆碱酯酶的可逆性抑制剂，及在相同浓度时对红细胞膜有稳定作用。文中初步探讨了安定的这些作用在有机磷中毒的治疗中所起的作用。
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| 关 键 词： | 安定 胆碱酯酶 有机磷 膜稳定性 |
Effects of Diazepam on Rat Cholinesterase andMembrane Stability of
Red Cell in vitro |
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| Zhi-Yi Liu,Bao-Guo Liu,Cai-Li Zhang.Effects of Diazepam on Rat Cholinesterase andMembrane Stability of
Red Cell in vitro[J].Journal of Chinese Pharmaceutical Sciences,1995,4(1):17-21. |
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| Authors: | Zhi-Yi Liu Bao-Guo Liu Cai-Li Zhang |
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| Abstract: | The results confirmed that
diazepam inhibits the
cholinesterase in rat serum,red cell,corpus striatum and diaphragm in
vitro,that the higher the diazepam concentration,the stronger the
cholinesterase inhibition,and that diazepam is a reversible inhibitor
to acetylcholinesterase and diazepam has a stabilizing action on red
cell membranes.The role of these effects of diazepam in the treatment
of organic phosphate poisoning is discussed |
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| Keywords: | Diazepam Cholinesterase Organic phosphate Membrane stabiliy present Address:Department of Pharmacology Institute Materia Medica Chinese Academy of Medical Sciences Beijing 100050 |
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