双草退黄冲剂1号治疗急性黄疸型肝炎深度黄疸的临床与实验研究

目的观察双草退黄冲剂1号治疗急性黄疸型肝炎深度黄疸患者的临床疗效并探讨其作用机理。方法对34例急性黄疸型肝炎深度黄疸患者(治疗组)在西医常规治疗的基础上加用口服双草退黄冲剂1号治疗4周，分析其黄疸消退情况及疗效等，与同期西医常规治疗22例(对照组)作比较。并通过动物实验观察其对小鼠D-半乳糖胺急性肝损伤、肝脏超氧化物歧化酶(SOD)及血清丙氨酸转氨酶(ALT)、天冬氨酸转氨酶(AST)的影响。结果治疗组显效率和有效率分别为73.5%(25/34例)和23.5%(8/34例)，对照组为59.1%(13/22例)和40.9%(9/22例)，两组显效率比较差异有显著性(P＜0.05)；实验研究显示双草退黄冲剂1号大、中剂量组肝损伤轻微，疗效明显优于模型组，且使肝脏SOD活性升高及血清ALT、AST降低(P＜0.05，P＜0.01)。结论双草退黄冲剂1号可加快黄疸消退、改善肝功能及减轻肝损伤，其机理可能与提高SOD活性，清除氧自由基有关。

Clinical and Experimental Study of Shuangcao Tuihuang Granule-1 in Treating Severe Jaundice of Acute Icterohepatitis

Objective: To observe the effect of Shuangcao Tuihuang Granule 1 (SCTH 1) in treating severe jaundice of acute icterohepatitis and to study its mechanism. Methods: Thirty four patients with severe jaundice of acute icterohepatitis were treated with SCTH 1, their therapeutic effects were analyzed. In the experimental studies, the influences of SCTH 1 on acute liver injury, liver superoxide dismutase (SOD) and serum ALT and AST were monitored. Results: The markedly effective rate and effective rate of the treated group were 73.5% and 23.5% respectively. The markedly effective rate of the treated group was obviously higher than that of the control group (P<0 05). Experimental study revealed that SCTH 1 could reduce the level of serum transaminase and inflammation of liver tissue in mice with acute liver damage. In addition, SCTH 1 could raise the activity of liver SOD (P<0 05). Conclusion: SCTH 1 could accelerate the jaundice subsidence, improve the liver function and ameliorate the liver injury, its mechanism was possibly correlated with raising SOD activity, scavenging the oxygen free radicals.