The protective effect of profound hypothermia on the canine central nervous system during one hour of circulatory arrest |
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| Authors: | J V O'Connor T Wilding P Farmer J Sher M A Ergin R B Griepp |
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| Institution: | 1. CHU de Québec Research Center CHU de Québec – Université Laval, Quebec City, QC, Canada;2. Department of Medicine, Division of Nephrology, Université Laval, Quebec City, QC, Canada;3. Department of Anesthesiology and Critical Care Medicine, Université Laval, Quebec City, QC, Canada;4. Centre antipoison du Québec, Quebec City, QC, Canada;5. Department of Family Medicine and Emergency Medicine, Université Laval, Quebec City, QC, Canada;1. Department of Emergency Medicine, School of Medicine, University of Utah, Salt Lake City, Utah, USA;2. BC RESURECT: Department of Emergency Medicine, University of British Columbia, Vancouver, BC, Canada;3. Salt Lake City Fire Department, Salt Lake City, Utah, USA;1. College of Medicine and Public Health, Flinders University, Bedford Park SA 5042, Australia;2. University of Adelaide, Adelaide SA 5005, Australia;3. Royal Adelaide Hospital, Central Adelaide Local Health Network, Adelaide SA 5000, Australia;4. Queen Elizabeth Hospital, Central Adelaide Local Health Network, Woodville SA 5011, Australia;5. Gold Coast University Hospital, Southport QLD 4215, Australia;6. Flinders Medical Centre, Southern Adelaide Local Health Network, Bedford Park SA 5042, Australia |
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| Abstract: | Circulatory arrest during profound hypothermia is a safe technique of cardiac surgery when used in selected instances. Despite its proven safety, the degree of cerebral protection offered by this technique is still poorly defined. Ten dogs anesthetized with Pentothal (thiopental sodium) were surface cooled to 32 degrees C. They were placed on cardiopulmonary bypass, cooled to 13 degrees C (cerebral temperature), and then underwent one hour of circulatory arrest. At the end of the arrest period, the dogs were rewarmed, resuscitated, and successfully weaned from bypass. A control group of 6 dogs were subjected to the same protocol but without the one-hour period of circulatory arrest. There were no group differences in animal weight, duration of surface cooling, cardiopulmonary bypass, or rewarming, mean flow, or mean arterial pressure. After a 7-day observation period, the dogs were killed with rapid tissue fixation using formalin. No neurological deficits were noted in any of the dogs during the observation period. The fixed brains were examined by a neuropathologist. No gross or microscopic evidence of cerebral hypoxia was seen in any of the animals. We conclude that one hour of circulatory arrest under profoundly hypothermic temperatures produces no detectable neurological changes or histological evidence of cerebral hypoxia. |
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